Project Details
Synergistic effects of a high-salt diet (HSD) and chronic psychological stress on antibacterial immune responses (P14)
Subject Area
Immunology
Nephrology
Cell Biology
Nephrology
Cell Biology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352
We could show that a high-salt diet (HSD) suppressed neutrophil function by elevating corticosterone levels, which suppressed neutrophil maturation in the bone marrow and compromised the defense against bacterial infections. Additionally, we discovered that coinciding psychological stressors exacerbated such immune suppression in mice. We now aim to analyze whether stress and HSD synergistically affect metaflammation and stress vulnerability, thereby predisposing individuals to life-style diseases.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1454:
Metaflammation and Cellular Programming
Applicant Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Project Heads
Dr. Anne-Kathrin Gellner, since 1/2025; Professor Dr. Christian Kurts