Impact of Metaflammation on hepatic macrophage function in tissue regeneration (P10)

• Subject Area: Immunology ; Gastroenterology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

Obesity is a risk factor for drug-induced liver injuries (DILI) and poor liver regeneration. Liver-resident macrophages (Kupffer Cells, KCs) play a significant role in liver regeneration as their depletion suppresses liver regeneration and increases mortality. This project aims to unravel the metaflammation-induced cellular and molecular mechanisms that are responsible for the transcriptional reprogramming of hepatic macrophages and their precursors, which result in altered KC reconstitution and functional dysregulation during liver regeneration after acute liver injury or surgical resection.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professorin Dr. Zeinab Abdullah