The importance of ILC2-intrinsic lipid metabolism for the prevention of metaflammation (P07)

• Subject Area: Immunology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

Recent data suggest that group 2 innate lymphoid cells (ILC2) residing in the adipose tissue may play an important role in maintaining the metabolic health and energy balance of the organisms. Our data indicates that lipid metabolism and the capacity of ILC2 to store lipids could be essential for the maintenance and protective function of such cells. This project aims to understand how metabolic alterations in obesity impact lipid metabolism and maintenance of adipose tissue ILC2, and whether manipulation of these pathways in ILC2 could prevent the progression of metaflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Christoph Wilhelm, Ph.D.