Retuning motor network disorders using neuromodulation of spinal sensory afferents (A03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Clinical Neurology; Neurosurgery and Neuroradiology ; Cognitive, Systems and Behavioural Neurobiology ; Molecular and Cellular Neurology and Neuropathology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

In the first funding period, we have uncovered two potential mechanisms of spinal neuromodulation for gait restoration: the remote modulation of supraspinal networks with high-frequency cervical stimulation and the local modulation of leg muscles with low-frequency lumbar stimulation. We will apply these two techniques in combination with gait rehabilitation training to promote motor recovery in animal models of Parkinson’s disease and stroke. Collaborations within ReTune will allow us to interpret network plasticity at the neural, MRI and histological levels and to identify the circuits responsible for gait recovery using pharmacogenetic tools. These conceptual foundations will facilitate the design of future clinical trials within ReTune.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Matthias Endres; Professor Dr. Christoph Harms; Nikolaus Wenger, Ph.D.