TRR 319:  RMaP: RNA Modification and Processing

• Subject Area: Biology ; Medicine
• Term: since 2021
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

No abstract available

• DFG Programme: CRC/Transregios

Current projects

• A01 - Functional roles of 5-methylcytosine (m5C) in regulating cell fate in normal tissues and human disease (Project Heads Frye, Ph.D., Michaela ;  Lyko, Frank ;  Schirmeister, Tanja )
• A02 - Multiple capping and decapping pathways for NAD-modified RNAs and their relation of RNA processing (Project Head Jäschke, Andres )
• A03 - Impact of RNA modifications on RNA processing and stimulation of innate immune Toll-like receptors 7/8 (Project Heads Butter, Falk ;  Dalpke, Alexander )
• A04 - Ensemble analysis of mRNA editing, modification and processing in macrophages (Project Heads Papavasiliou, Ph.D., F. Nina ;  Stoecklin, Georg )
• A05 - Dynamics of modifications and processing of RNAs in the flavivirus replication cycle (Project Heads Helm, Mark ;  Ruggieri, Ph.D., Alessia )
• A06 - Interplay between tRNA splicing and tRNA modifications (Project Heads Peschek, Jirka ;  Tuorto, Francesca )
• B01 - The mechanistic and functional impact of RNA modifications on alternative splicing (Project Heads Dieterich, Christoph ;  König, Ph.D., Julian ;  Roignant, Jean-Yves )
• B03 - Molecular insights into the role of MTREC in ncRNA processing and degradation (Project Head Sinning, Irmgard )
• B04 - Identification and processing of piRNA precursors in C. elegans (Project Head Ketting, Ph.D., René )
• B05 - Mismodification of tRNA in no-go decay and other co-translational quality control pathways (Project Head Winz, Marie-Luise )
• B06 - Assembly, activity, and structural dynamics in eukaryotic H/ACA complexes (Project Head Hengesbach, Martin )
• C01 - Novel modification mapping techniques and efficient RNA-Seq data management (Project Heads Helm, Mark ;  Hildebrandt, Andreas ;  Schmidt, Bertil )
• C02 - SCI-MODOM – Integration and Management of RNA modification data (Project Heads Dieterich, Christoph ;  Hildebrandt, Andreas )
• C03 - C03 Mass spectrometry of RNA and proteins in modified RNPs (Project Heads Butter, Falk ;  Helm, Mark ;  Jäschke, Andres )
• IRTGMGK - Integrated Research Training Group (Project Head Ruggieri, Ph.D., Alessia )
• Z - Central Task of the Collaborative Research Center (Project Head Helm, Mark )

• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Co-Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Spokesperson: Professor Dr. Mark Helm