SFB 1279:  Exploiting the Human Peptidome for Novel Antimicrobial and Anticancer Agents

• Subject Area: Medicine ; Biology ; Chemistry ; Materials Science and Engineering ; Physics
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316249678

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Identification and functional optimization of antimicrobial peptides with activity against Mycobacterium tuberculosis (Project Heads Michaelis, Jens ;  Stenger, Steffen )
• A02 - Identification and characterization of antimicrobial peptides from major pathogen entry and replication sites (Project Heads Münch, Jan ;  Spellerberg, Barbara )
• A03 - Amyloid biology of bioinspired peptides - from basic research to preclinical development (Project Heads Fändrich, Marcus ;  Münch, Jan ;  Walther, Paul )
• A04 - Characterization of novel peptide ligands of GPCRs involved in lentiviral infections (Project Head Kirchhoff, Frank )
• A05 - Peptides targeting the fusion peptides of enveloped viral pathogens (Project Heads Kirchhoff, Frank ;  Weil, Tanja )
• A06 - Characterization and optimization of the CXCR4 antagonist EPI-X4 (Project Heads Klein, Florian ;  Münch, Jan ;  Sanchez Garcia, Elsa )
• A07 - Endogenous peptides as novel inhibitors of the Bordetella pertussis toxin (Project Heads Barth, Holger ;  Ernst, Katharina )
• A08 - Regulation of autophagy by human peptides and exploration of their anti-microbial and anti-cancer properties (Project Head Sparrer, Konstantin )
• B01 - Characterization of endogenous peptides targeting leukemic stem cells in acute myeloid leukemia (Project Head Buske, Christian )
• B03 - Identification of endogenous peptides for the treatment of transformed B cells (Project Heads Jumaa, Hassan ;  Übelhart, Rudolf )
• B05 - Identification and mechanism of human peptides protecting against therapy-induced leukemia (Project Heads Gebhardt, Christof ;  Wiesmüller, Elisabeth Maria )
• C01 - Synthesis of peptide and protein biohybrids with improved features (Project Heads Barth, Holger ;  Otto, Markus ;  Weil, Tanja )
• C02 - Biohybrid transporters for cell type-specific delivery and controlled release of pharmacologically active peptides (Project Heads Barth, Holger ;  Michaelis, Jens )
• C03 - Mesoporöse Silica-Nanopartikel zur kontrollierten Freisetzung von Peptid-Wirkstoffen (Project Head Lindén, Mika )
• C04 - Fluorescent nanodiamonds as biocompatible markers and sensors for simultaneous peptide delivery and bioimaging (Project Heads Jelezko, Fedor ;  Weil, Tanja ;  Wu, Ph.D., Yuzhou )
• Z01 - Peptide libraries, purification, synthesis and structural analyses (Project Heads Jacob, Timo ;  Kaiser, Ute ;  Read, Clarissa ;  Ständker, Ludger ;  Wagner, Manfred ;  Wiese, Sebastian )
• Z02 - Peptide evaluation and molecular imaging in vivo (Project Heads Beer, Ambros ;  Rasche, Volker ;  Weidinger, Gilbert )
• Z03 - Central tasks of the CRC (Project Head Kirchhoff, Frank )

Completed projects

• B02 - Bioactive peptides in normal and compromised hematopoiesis (Project Head Geiger, Hartmut )
• B04 - Targeting CXCR4 signaling to eliminate metastatic cancer stem cells in pancreatic cancer (Project Head Hermann, Patrick C. )
• C06 - Hyperpolarized peptide-coated nanodiamonds for magnetic resonance imaging (Project Heads Buske, Christian ;  Jelezko, Fedor ;  Plenio, Martin Bodo )

• Applicant Institution: Universität Ulm
• Spokesperson: Professor Dr. Frank Kirchhoff