Interleukin-3 produzierende IRA B Zellen als Mediatoren der akuten und verzögerten Immunantwort während Entzündungsreaktionen

• Antragsteller: Professor Dr. Georg Weber
• Fachliche Zuordnung: Allgemein- und Viszeralchirurgie
• Förderung: Förderung von 2016 bis 2020
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 316129653

• Erstellungsjahr: 2020

Zusammenfassung der Projektergebnisse

Interleukin-3 has been identified as an important mediator during primary and secondary viral pneumonia and as a predictive marker during SARS-CoV-2 infections. Mechanistically, interleukin-3 led to the production of CXCL12 by CD123+ pulmonary epithelial cells leading to the recruitment of type 1 interferon producing circulating plasmacytoid dendritic cells. We identified the generation of interleukin-3 producing IRA B cells during other inflammatory condictions such as inflammatory bowl disease and pancreatitis which is currently investigated further. As well, interleukin-3 seems to play an important role during the development of malignant diseases such as colitis associated colorectal cancer and pancreatic adenocarcinoma.

Projektbezogene Publikationen (Auswahl)

• Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 2017 Jul;39(5):517-528
  Chousterman BG, Swirski FK, Weber GF
  (Siehe online unter https://doi.org/10.1007/s00281-017-0639-8)
• Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription. J Exp Med. 2017 Jul 3;214(7):2059-2071
  Ubieta K, Garcia M, Grötsch B, Uebe S, Weber GF, Stein M, Ekici A, Schett G, Mielenz D, Bozec A
  (Siehe online unter https://doi.org/10.1084/jem.20160514)
• Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response. Sci Immunol. 2017 Jan 6;2(7)
  Lehmann B, Biburger M, Brückner C, Ipsen-Escobedo A, Gordan S, Lehmann C, Voehringer D, Winkler T, Schaft N, Dudziak D, Sirbu H, Weber GF, Nimmerjahn F
  (Siehe online unter https://doi.org/10.1126/sciimmunol.aah6413)
• BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graftversus-host disease. J Clin Invest. 2018 Mar 1;128(3):916-930
  Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K
  (Siehe online unter https://doi.org/10.1172/JCI89242)
• Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis. ACS Nano. 2018 Apr 24;12(4):3378-3384
  Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H
  (Siehe online unter https://doi.org/10.1021/acsnano.7b08965)
• Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis - A meta-analysis. J Crit Care. 2018 Jun;45:71-75
  Krautz C, Maier SL, Brunner M, Langheinrich M, Giamarellos-Bourboulis EJ, Gogos C, Armaganidis A, Kunath F, Grützmann R, Weber GF
  (Siehe online unter https://doi.org/10.1016/j.jcrc.2018.01.013)
• Gata6(+) Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis. Immunity. 2019 Jul 16;51(1):131-140.e5
  Deniset JF, Belke D, Lee WY, Jorch SK, Deppermann C, Hassanabad AF, Turnbull JD, Teng G, Rozich I, Hudspeth K, Kanno Y, Brooks SR, Hadjantonakis AK, O’Shea JJ, Weber GF, Fedak PWM, Kubes P
  (Siehe online unter https://doi.org/10.1016/j.immuni.2019.06.010)
• The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLoS Pathog. 2020 Apr 23;16(4):e1008464
  Fernandes VE, Ercoli G, Bénard A, Brandl C, Fahnenstiel H, Müller-Winkler J, Weber GF, Denny P, Nitschke L, Andrew PW
  (Siehe online unter https://doi.org/10.1371/journal.ppat.1008464)