Professor Dr. Axel Methner

Address Johannes Gutenberg-Universität Mainz
Universitätsmedizin
Institut für Molekulare Medizin
Obere Zahlbacher Straße 67
55131 Mainz

ORCID-ID 0000-0002-8774-0057

Projects

As Applicant
- Current projects
  - Crosstalk between ferroptosis and sarmoptosis (Priority Programmes)
  - Charcot Marie Tooth disease 4A - GDAP1-mediated redox-dependent interaction of mitochondria with the cytoskeleton (Research Grants)
  - Contributions of ubiquitin signaling to the maintenance of mitochondrial import channels (Priority Programmes)
  - The role of NECAB2 in mitochondrial stress response (Research Grants)
- Completed projects
  - Mechanismen der Bl-1/Bcl-2-vermittelten Reduktion des ER-Kalziumgehalts und der damit verbundenen antipoptotischen Wirkung (Research Grants)
  - The role of NECAB2 in brain physiology and in Huntington s disease (Research Grants)
  - Sensor, channel, pump and leak - TMBIM6 assembles a multi-protein complex that governs the Ca2+ content of the endoplasmic reticulum (Research Grants)
  - Thiol switches controlled by the glutathione-S-transferase GDAP1 (Priority Programmes)
  - TMBIM5 is a Ca2+ channel in the inner mitochondrial membrane (Research Grants)
  - The role of the Fe/S cluster protein CISD1 in Parkinson’s disease (Research Grants)
As Project Head
- Current projects
  - Regulating Cellular Functions by Light-Gated Assembly of Phase-Separated Nanostructures (Optoaggregates) (Collaborative Research Centres)
- Completed projects
  - GDAP1 is a redox sensor that controls cellular redox homeostasis by altering mitochondrial shape and function (Collaborative Research Centres)