Project Details

Professor Dr. Ralf Weiskirchen

Address Rheinisch-Westfälische Technische Hochschule Aachen
Institut für Molekulare Pathobiochemie, Experimentelle Gentherapie
und Klinische Chemie (IFMPEGKC)
Pauwelsstraße 30
52074 Aachen

Projects

As Applicant
- Current projects
  - TGF-β signaling and cholesterol: interdependent and druggable targets in NASH (Research Grants)
  - Mechanisms controlling pro-inflammatory mast cell functions and implications for chronic liver disease and cancer (Research Grants)
  - Lipocalin 2, a key molecular switch in regulating liver metabolism and immunity (Research Grants)
- Completed projects
  - Biochemie und Pathophysiologie des LIM-Domänen Proteins CRP2, einem Marker hepatischer Sternzellen (Research Grants)
  - Exogene und endogene Modulatoren der PDGF/TGF-ß Signalwege bei fibrosierenden Lebererkrankungen und ihr therapeutischer Einsatz (Research Grants)
As Leader
- Completed projects
  - FACS-Sorter mit UV-Laser (Major Research Instrumentation)
As Project Head
- Completed projects
  - The cross-talk of BMP-7 and TGF-ß: Is BMP-7 the natural antagonist of TGF-ß in inflammatory liver diseases? (Collaborative Research Centres)
  - The impact of the LIM domain proteins FHL2 and CRP2 on hepatic stellate cell activation and its crosstalk with TGF-beta signalling pathways in hepatic fibrogenesis (CRC/Transregios)
  - Targeting CCN1/CYR61 as a new treatment modality in hepatic fibrosis (CRC/Transregios)
  - FACS-based cell isolation and clinical translation (CRC/Transregios)
As Participating Person
- Completed projects
  - Aktivierungsabhängige Expression TGFbeta-antagonisierender Proteinchimären in Lebersternzellen (hepatic stellate cells) in vitro und in situ nach adenoviraler Transfektion von Fusionsgenen mit zelltypischen Promotoren (Research Grants)
  - Stoffwechsel von Connective Tissue Growth Factor (CTGF/CCN2) und TGF-ß1 in Hepatozyten und deren pathogenetische Bedeutung für die Leberfibrose (Fibrogenese) (Research Grants)
As Co-Applicant
- Completed projects
  - Advanced Mass Spectrometry Imaging of Metals and Biomolecules in Brain and Liver (Major Instrumentation Initiatives)

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Professor Dr. Ralf Weiskirchen

Additional Information

Servicenavigation

Hauptnavigation

Professor Dr. Ralf Weiskirchen

Additional Information

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