Professor Dr. Mathias Walter Hornef

Address Universitätsklinikum Aachen, AöR
Institut für Medizinische Mikrobiologie
Pauwelsstraße 30
52074 Aachen

Projects

As Applicant
- Current projects
  - Impact of Disease Burden and Timing of Disease Initiation on the Response to Interferonalpha (IFNa) in MPN-associated myelofibrosis (Clinical Research Units)
  - Bacterial and host factors governing enterocyte exit of Salmonella (Priority Programmes)
- Completed projects
  - Toll-ähnliche Rezeptoren und ihre Bedeutung bei der gastrointestinalen Entzündungsreaktion (Research Fellowships)
  - Mechanisms that prevent inappropriate Toll-like receptor activation at the intestinal epithelium (Research Grants)
  - Between vigilance and tolerance: Innate immune signaling at the intestinal epithelium (Research Grants)
  - In vivo Formation and Maintenance of Salmonella-Containing Vacuoles (SCVs) in Enterocytes using a Novel Neonatal Mouse Model (Priority Programmes)
  - Host control of persistent Salmonella infection (Research Grants)
  - Host control of the enteric microbiota during the postnatal period (Priority Programmes)
  - The in vivo response of the intestinal epithelium to bacterial infection (Research Grants)
  - Functional analysis of gut microbiome-host interactions during the postnatal window of opportunity by a multiscale sequencing approach (Research Grants)
As Participating Researcher
- Completed projects
  - GRK 1273: Strategies of Human Pathogens to Establish Acute and Chronic Infections (International Research Training Groups)
As Project Head
- Current projects
  - Nutrition, host metabolism and the antimicrobial response to enteric infection in the neonatal host (CRC/Transregios)
  - Enterohepatic cooperation in the postnatal establishment of immune homeostasis (Collaborative Research Centres)
  - Integrated Research Training Group ‘Gut-Liver Axis’ (Collaborative Research Centres)
- Completed projects
  - The role of antimicrobial peptides for the establishment and maintenance of the intestinal host-microbe homeostasis (Collaborative Research Centres)
  - Mechanisms of host-bacteria homeostasis on the intestinal epithelium (Collaborative Research Centres)
As Co-Investigator
- Completed projects
  - Homeostatic and infection-induced adaptive immunity in the neonatal small intestine and its functional consequences (Research Grants)