Professor Dr. Michael Gotthardt

Address Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Forschungsgruppe Neuromuskuläre und kardiovaskuläre Zellbiologie
Robert-Rössle-Straße 10
13125 Berlin

Projects

As Applicant
- Current projects
  - A proteomics approach to titin kinase mechanosignaling in striated muscle. (Research Grants)
  - Titin in vascular smooth muscle – from scaffold to mechanosensor (Research Grants)
- Completed projects
  - Erzeugung und Charakterisierung eines Tiermodells zur Herzinsuffizienz durch genetische Veränderung des Proteasemetabolismus (Research Fellowships)
  - Mechanische und Stoffwechsel-Funktion des Muskelproteins Titin (Research Grants)
  - Titin in Biomechanik, Signaltransduktion und Stoffwechsel- Funktionelle Analyse der N2B-Region im Vergleich der Geschlechter (Research Grants)
  - Alternatives Spleißen in der perinatalen Herz-Entwicklung und bei Kardiomyopathie (Research Grants)
  - Titin-based mechanotransduction in skeletal muscle atrophy and hypertrophy (Clinical Research Units)
  - The Coxsackievirus and Adenovirus Receptor CAR in Cardiac Remodeling (Research Grants)
  - Z-disc Titin in Sarcomere Assembly and Mechanotransduction (Research Units)
  - Regulation of RBM20 expression and activity in cardiac development and disease (Research Grants)
  - Role of the Coxsackievirus and Adenovirus Receptor CAR in Synaptic Transmission and Memory Formation (Research Grants)
  - Titin in the pregnant uterus – a loss of function approach to smooth muscle biomechanics and mechanosignaling (Research Grants)
As Spokesperson
- Current projects
  - SFB 1470: Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies (Collaborative Research Centres)
As Participating Researcher
- Completed projects
  - GRK 1631: MyoGrad - International Research Training Group for Myology (International Research Training Groups)
As Project Head
- Current projects
  - A systems and translational approach to titin dynamics in HFpEF (Collaborative Research Centres)
  - Animal models and human Engineered Heart Tissue (Collaborative Research Centres)
  - Central Administrative Project (Collaborative Research Centres)
- Completed projects
  - Analysis of the Coxsackievirus-Adenovirus-Receptor (CAR) in the Pathogenesis of Cardiomyopathies (CRC/Transregios)