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Professor Dr. Walter Nickel

Address Ruprecht-Karls-Universität Heidelberg
Biochemie-Zentrum (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg

Projects

As Applicant
- Current projects
  - Dissecting the role of the Na,K-ATPase in unconventional secretion of Fibroblast Growth Factor 2 (Research Grants)
  - Structure-function relationship of FGF2 oligomers forming dynamic membrane pores in unconventional protein secretion (Research Grants)
- Completed projects
  - ER/Golgi-unabhängige Protein-Sekretion: Identifizierung und funktionelle Charakterisierung der molekularen Export-Maschinerie (Research Grants)
  - UPS - Unconventional Protein Secretion (Research Grants)
  - Exploring the structure function relationship of membrane-pore-forming FGF2 oligomers - a single molecule approach (Research Grants)
  - Dissecting the Role of ATP1A1 in Unconventional Secretion of Fibroblast Growth Factor 2 (Research Grants)
  - Development of small molecule inhibitors blocking unconventional secretion of Fibroblast Growth Factor 2, a potent tumour cell survival factor - Knowledge Transfer Project (Research Grants)
  - Exploring the structure-function relationship of membrane-pore-forming FGF2 oligomers - a single molecule approach (Research Grants)
As Spokesperson
- Current projects
  - TRR 186: Molecular Switches: Spatio-temporal Control of Cellular Signal Transmission (CRC/Transregios)
- Completed projects
  - GRK 1188: Quantitative Analysis of Dynamic Processes in Membrane Transport and Translocation (Research Training Groups)
As Participating Researcher
- Completed projects
  - GRK 230: Molecular Cell Biology (Research Training Groups)
As Project Head
- Current projects
  - Molecular switches in the spatio-temporal coordination of the FGF2 membrane translocation machinery (CRC/Transregios)
  - Central Coordination (CRC/Transregios)
  - Molecular mechanism driving disulfide formation during FGF2 oligomerization and membrane translocation (Collaborative Research Centres)
  - Mechanical and chemical crosstalk between membranes and anchored mechano-kinases (Collaborative Research Centres)
- Completed projects
  - Plasmamembran-Transport und Externalisierung von Leishmania HASPB: ein Zelloberflächenfaktor mit unmittelbarer Bedeutung für Wirtszellinfektion und die intrazelluläre Überlebensfähigkeit von Leishmania Parasiten (Collaborative Research Centres)
  - Molekualre Mechanismen der bildung von Transportvesikeln (Collaborative Research Centres)
  - Unconventional Protein Secretion (Collaborative Research Centres)
  - Molecular machinery mediating FGF2 membrane translocation in unconventional secretion (CRC/Transregios)

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