Charité - Universitätsmedizin Berlin
CharitéCentrum für Grundlagenmedizin (CC2)
Institut für Physiologie
Address
Charitéplatz 1
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Research Units
Completed projects
Adaptation terminaler Gefäßbetten: Einfluß hämodynamischer Faktoren auf Netzwerktopologie, Gefäßstruktur und -tonus
(Applicant
Pries, Axel Radlach
)
Molekulare Mechanismen der Adaptation von Endothelzellen an Strömungsbedingungen
(Applicant
Zakrzewicz, Andreas
)
Priority Programmes
Completed projects
Nicotine cessation and withdrawal: alterations in neuroendocrine and sleep-polysomnographic parameters as predictors of relapse
(Applicants
Riemann, Dieter
;
Rodenbeck, Andrea
)
Regulation of vascular permeability by sphingolipids
(Applicants
Kübler, Wolfgang
;
Uhlig, Stefan
)
Synaptic inhibition in substantia migra, neostriatum and hippocampus of the "weaver" mouse
(Applicant
Misgeld, Ulrich
)
Research Grants
Current projects
Investigating the Pathophysiology of Pulmonary Arterial Hypertension with Organ-on-Chip Technology
(Applicant
Kübler, Wolfgang
)
PML- and Smyd1-dependent regulatory mechanisms and effects on inflammatory responses of vascular endothelial cells
(Applicant
Berkholz, Janine
)
RUNX2-mediated pulmonary artery remodeling as a pathomechanism and therapeutic target in pulmonary hypertension due to left heart disease
(Applicants
Knosalla, Christoph
;
Kucherenko, Mariya
;
Kübler, Wolfgang
)
Sodium-coupled neutral amino acid transporter SNAT2 – a regulatory hub of alveolar homeostasis and its critical role in acute lung injury/ARDS
(Applicant
Kübler, Wolfgang
)
Completed projects
Cellular mode of action and spectrum of application of angiotensin-(1-7) for the treatment of acute lung injury and systemic inflammatory diseases
(Applicant
Kübler, Wolfgang
)
Die subakute endotheliale Aktivierung in der myokardialen Reperfusion und ihre Bedeutung für den Reperfusionsschaden des Herzens
(Applicant
Kupatt, Christian
)
Molekulare Charakterisierung von Endothelien unterschiedlicher Primärlokalisation
(Applicant
Zakrzewicz, Andreas
)
Pathomechanismus und therapeutische Beeinflußbarkeit des durch Thrombozyten/Leukozyten vermittelten myokardialen Reperfusionsschadens
(Applicant
Boekstegers, Peter
)
Quantitative Analyse der Totraumventilation in Tiermodellen des akuten Lungenschadens
(Applicants
Guttmann, Josef
;
Kübler, Wolfgang
;
Meinzer, Hans-Peter
;
Puderbach, Michael
;
Thiele, Frank
)
Regulation of lung vascular permeability by lysosomal trafficking
(Applicants
Kübler, Wolfgang
;
Uhlig, Stefan
)
Strömungsmechanik und Zellphysiologie in der Alveole und ihren Kapillaren
(Applicants
Affeld, Klaus
;
Kübler, Wolfgang
)
The role of microRNAs for the regulation of stress-induced tissue factor isoform expression of human endothelial cells and mononuclear leukocytes
(Applicant
Rauch-Kröhnert, Ursula
)
Collaborative Research Centres
Current projects
Cardio-pulmonary interaction in HFpEF
(Project Heads
Grune, Jana
;
Kübler, Wolfgang
)
The alveolar epithelial glycocalyx at the blood-gas barrier of the lung
(Project Heads
Kübler, Wolfgang
;
Ochs, Matthias
)
Completed projects
In situ Untersuchungen zu physiologischen Mechanismen der Mikrogliaaktivierung unter pathophysiologischen Bedingungen
(Project Heads
Eder, Claudia
;
Schilling, Tom
)
Kartierung von Rezeptor-Ligand-Wechselwirkungen mittels Peptid-Bibliotheken
(Project Heads
Preissner, Robert
;
Volkmer, Rudolf
)
CRC/Transregios
Completed projects
Characterization of the Cardiovascular Phenotype and Experimental Therapeutic Approaches in Animal Models
(Project Heads
Kübler, Wolfgang
;
Riad, Alexander
;
Tschöpe, Carsten
)
FXII – between hypercoagulation and fibrinolysis shutdown in COVID-19
(Project Heads
Hackstein, Holger
;
Kübler, Wolfgang
;
Preissner, Klaus T.
;
Wygrecka, Malgorzata
)
Protective effect of CFTR modulators on endothelial barrier failure in COVID-19 induced ARDS
(Project Heads
Kübler, Wolfgang
;
Suttorp, Norbert
;
Witzenrath, Martin
)
Clinical Research Units
Current projects
Data analysis, data integration and rule-based modeling of food allergy
(Applicants
Banerjee, Ph.D., Priyanka
;
Forslund-Startceva, Sofia
;
Roll, Stephanie
)
KFO 339: Food Allergy and Tolerance (Food@)
(Spokesperson
Worm, Margitta
)
Research Training Groups
Completed projects
GRK 238: Mechanisms of Damage in CNS Disease - Application of Imaging Techniques
(Spokesperson
Heinemann, Uwe
)
GRK 865: Mechanisms of Vasoregulation
(Spokesperson
Kübler, Wolfgang
)
International Research Training Groups
Completed projects
GRK 1360: Genomics and Systems Biology of Molecular Networks
(Spokesperson
Klipp, Edda
)
