Technische Universität Dresden
Center for Molecular and Cellular Bioengineering (CMCB)
Biotechnologisches Zentrum (Biotec)
Address
Tatzberg 47/49
01307 Dresden
Deutschland
GERiT
This institution in GERiT
01307 Dresden
Projects
Priority Programmes
Current projects
Molecular mechanisms and physiological functions of DNA damage condensates
(Applicants
Alberti, Simon
;
Seidel, Claus
)
Nuclear pore complex proteins-directed 3D nuclear architecture in neural development and disease
(Applicants
Poetsch, Anna
;
Toda, Ph.D., Tomohisa
)
Phase separation of membrane scaffolding proteins as a mechanism to control formation of tight junctions
(Applicants
Honigmann, Alf
;
Weber, Christoph
)
Completed projects
Development of a Combined Fluorescence, Optical Diffraction Tomography and Brillouin (FOB) Microscope for the Quantitative Investigation of Phase Transitions in Cells
(Applicants
Alberti, Simon
;
Guck, Jochen
)
Dissecting the role/s of breast cancer cell membrane protrusions in invasion, colonization and transformation of the bone marrow microenvironment: From cell biology to clinical applications
(Applicants
Corbeil, Denis
;
Wimberger, Pauline
)
Functional examination of H3K4 methyltransferases in myeloid neoplasia
(Applicants
Kranz, Andrea
;
Stewart, Adrian Francis
)
Identification and characterization of genes encoding proteins with polar expression in different Drosophila cells
(Applicant
Klämbt, Christian
)
Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis
(Applicant
Grill, Stephan Wolfgang
)
Prominin-1-GFP knock-in mouse line: A novel source of fluorescent stem cells to monitor the history of the transplanted murine hematopoietic stem cells
(Applicant
Corbeil, Denis
)
Regulation of pluripotency and lineage decisions by histone methylation
(Applicant
Stewart, Adrian Francis
)
The role of chromatin modifications in the efficiency of reprogramming
(Applicant
Anastassiadis, Konstantinos
)
We propose to analyze how membrane trafficking and the tissue polarity proteins control junctional remodeling and prepupal wing morphogenesis
(Applicant
Eaton, Suzanne
)
Zoomable Cell
(Applicants
Gumhold, Stefan
;
Schroeder, Michael
)
Research Fellowships
Completed projects
Assessing the functional multiplicity of prion-based epigenetic inheritance in the yeast Saccharomyces cerevisiae and elucidating the impact of prions on the biology and the evolution of yeast
(Applicant
Alberti, Simon
)
Die Entwicklung des vaskulären und neuronalen Systems nach konditionaler Deletion der Rezeptortyrosinkinase Flk1
(Applicant
Kranz, Andrea
)
Unlocking the mechanism of kallikreins modulating the adhesion of prostate cancer cells to bone
(Applicant
Taubenberger, Ph.D., Anna
)
Research Grants
Current projects
Analysis of concerted sleep control through populations of GABAergic neurons of PZ and VLPO brain regions
(Applicant
Bringmann, Henrik
)
Bridging the scales between single cell and tissue mechanics towards improved tumor diagnostics
(Applicants
Aland, Sebastian
;
Taubenberger, Ph.D., Anna
)
Do H3K4 methyltransferases MLL4 and MLL3 instruct the mammalian body plan?
(Applicants
Kranz, Andrea
;
Stewart, Adrian Francis
)
Identifying the epigenetic regulatory mechanisms that drive the response of liver ductal cells to damage
(Applicants
Dahl, Andreas
;
Huch, Meritxell
)
Mechanisms of sleep induction by a sleep-active neuron
(Applicant
Bringmann, Henrik
)
Molecular and cellular mechanisms underlying the control of gene expression by a sleep-active neuron revealed by single-cell sequencing
(Applicant
Bringmann, Henrik
)
Molecular mechanisms of how increased sleep propensity promotes activation of a sleep-active neuron
(Applicant
Bringmann, Henrik
)
Phase separation as a survival strategy: stress protection by translation factor condensates
(Applicant
Alberti, Simon
)
Reactivation and reprogramming of spinal progenitors into a unique neuro-regenerative state
(Applicants
Becker, Catherina Gwynne
;
Poetsch, Anna
)
Sleep neuron control of starvation resistance
(Applicant
Bringmann, Henrik
)
Completed projects
A Tibetan Cradle of Evolution - in-situ speciation and Out-of-Tibet radiations in passerine model species
(Applicant
Päckert, Martin
)
Cell biology of osteoclasts: GTPases, exchange factors and actin dynamics during bone degradation
(Applicant
Hoflack, Bernard
)
Cell biology of osteoclasts II: PSTP1, an adaptor of protein tyrosine phosphatases, as a major component controlling of actin and sealing zone dynamics during bone degradation
(Applicant
Hoflack, Bernard
)
Contributions of the H3K27 demethylases UTX (KDM6A) and UTY (KDM6C) to hematopoiesis and sex specific differences in gene expression
(Applicant
Anastassiadis, Konstantinos
)
Control and functions of wounding-induced sleep in C. elegans
(Applicant
Bringmann, Henrik
)
Control of sleep-like behavior through a kinase and an ion channel subunit
(Applicant
Bringmann, Henrik
)
Genome-wide functional screen of lysosome biogenesis
(Applicant
Hoflack, Bernard
)
Identification and characterization of Long COVID-19 patients by whole blood transcriptomics
(Applicants
Aschenbrenner, Anna
;
Bals, Robert
;
Bonifacio, Ph.D., Ezio
;
Gagneur, Julien
;
Janssen, Stefan
;
Keitel-Anselmino, Verena
;
Keller, Andreas
;
Kurth, Ingo
;
Kurth, Florian
;
Kühnert, Denise
;
Nürnberg, Peter
;
Ossowski, Ph.D., Stephan
;
Poetsch, Anna
;
Riess, Olaf
;
Rosenstiel, Ph.D., Philip Caspar
;
Sander, Leif Erik
;
Schultze, Joachim L.
;
Stegle, Ph.D., Oliver
;
Ulas, Thomas
)
Identification of dietary lipid cues that regulate metabolism in Drosophila.
(Applicant
Brankatschk, Ph.D., Marko
)
Initiation of homologous recombination by Red beta and other single strand annealing proteins
(Applicant
Stewart, Adrian Francis
)
Investigating lineage decisions and migration mechanisms of cone photoreceptors in the developing zebrafish retina
(Applicant
Honigmann, Alf
)
Lipid Specific - Molecular Determinants of Sterol-Sphingolipid-Protein Interactions in Living Cells and Organisms
(Applicants
Eaton, Suzanne
;
Knölker, Hans-Joachim
;
Kurzchalia, Teymuras
)
Molecular and cellular characterization of prominin-like molecules in urodele amphibian - A unique model to study central nervous system regeneration
(Applicant
Corbeil, Denis
)
Nuclear architectural aspects of the histone 3 lysine 4 methyltransferase subclass of trithorax-Group action
(Applicant
Stewart, Adrian Francis
)
Protein targeting to endosomes/lysosomes: function of Septins in AP-3-dependent transport
(Applicant
Hoflack, Bernard
)
Protein targeting to endosomes/lysosomes II: protein networks regulating bidirectional transport between the trans-Golgi network and endosomes
(Applicant
Hoflack, Bernard
)
Rationalizing in vitro evolution by structural principles- Implications for target specificity of site-specific DNA recombinases.
(Applicant
Pisabarro, María Teresa
)
Reconstitution of clathrin/AP-1 coated membrane microdomains on proteoliposomes
(Applicant
Hoflack, Bernard
)
Structure-based design of Anaphase Promoting Complex/Cyclosome (APC/C) inhibitors as leads for drug development: an experimental and computational approach
(Applicants
Mansfeld, Jörg
;
Pisabarro, María Teresa
)
The chemistry and physics of cellular shutdown: unraveling how and why cells enter into a hypometabolic state
(Applicant
Alberti, Simon
)
The relationship between Mll1 and Notch signaling in epithelial stem cell homeostasis
(Applicant
Stewart, Adrian Francis
)
The role of lipoprotein association in Hedgehog release, trafficking and signalling
(Applicant
Eaton, Suzanne
)
Tracing the molecular evolution of the centrosome: adaptation of components and function
(Applicant
Kuhn, Michael
)
Emmy Noether Independent Junior Research Groups
Completed projects
How Ubiquitylation Coordinates Cell Division and Differentiation - Function and Regulation of E3 Ubiquitin Ligases Beyond the Cell Cycle
(Applicant
Mansfeld, Jörg
)
Research Units
Current projects
A01 Cell-microenvironment mechanical interactions in cancer from single cells to tissues
(Applicants
Huch, Meritxell
;
Taubenberger, Ph.D., Anna
)
FOR 2599: Tissue type 2 responses: Mechanisms of induction and regulation
(Spokesperson
Roers, Axel
)
FOR 5628: Multiscale magnetic resonance elastography in cancer: The mechanical niche of tumor formation and metastatic spread – towards an improved diagnosis of cancer through mechanical imaging
(Spokesperson
Sack, Ingolf
)
Service project: Single cell transcriptional profiling and bioinformatics
(Applicants
Dahl, Andreas
;
Roers, Axel
)
Completed projects
Automatic Generation of Description Logic-based Biomedical Ontologies
(Applicants
Baader, Franz
;
Schroeder, Michael
)
Coordination Funds
(Applicant
Brankatschk, Ph.D., Marko
)
FOR 2682: Seasonal temperature acclimation in Drosophila
(Spokesperson
Brankatschk, Ph.D., Marko
)
How does insulin signaling increase developmental success at high temperature? A biophysical and metabolic analysis
(Applicant
Brankatschk, Ph.D., Marko
)
Hybrid Reasoning Over Dynamic Protein Interaction Networks
(Applicants
Brewka, Gerhard
;
Schaub, Torsten
;
Schroeder, Michael
)
Microbes and heat resistance of Drosophila
(Applicant
Brankatschk, Ph.D., Marko
)
Collaborative Research Centres
Completed projects
Cellular and molecular mechanisms underlying the interaction of transplanted prominin-1/CD133+ hematopoietic stem cells with mesenchymal stem cells - An essential step in the reconstitution of the hematopoietic system
(Project Head
Corbeil, Denis
)
Characterization and functional relevance of nanotubular highway-like structures that physically link hematopoietic stem and progenitor cells over long distances
(Project Head
Corbeil, Denis
)
Conditional immortalization using mouse embryonic stem (ES) cells and mice to explore lineage commitment
(Project Heads
Anastassiadis, Konstantinos
;
Stewart, Adrian Francis
)
Elucidation of molecular networks controlling lineage commitment of bone marrow mesenchymal stromal cells
(Project Heads
Anastassiadis, Konstantinos
;
Stewart, Adrian Francis
)
Untersuchungen zur Funktion des Hämochromatosegens HLA-H bei der Regulation der intestinalen Eisenaufnahme
(Project Heads
Riedel, Hans-Dieter
;
Stewart, Adrian Francis
;
Stremmel, Wolfgang
)
CRC/Transregios
Current projects
Biomolecular condensates as sensors of nucleic acids
(Project Head
Alberti, Simon
)
Immunometabolic regulation of adrenal glucocorticoid production and peripheral glucocorticoid signalling
(Project Heads
Alexaki, Vasileia Ismini
;
Eaton, Suzanne
;
Henneicke, Ph.D., Holger
)
Completed projects
Establishment of plasma membrane domain identity in epithelial cells
(Project Head
Honigmann, Alf
)
Lipid rafts and obesity: function of OBR-GRP and endospanin, two lipid raft-associated tetraspanins, in the leptin recceptor trafficking
(Project Head
Hoflack, Bernard
)
Modeling and simulation of glycosaminoglycan/protein interactions
(Project Head
Pisabarro, María Teresa
)
Molecular mechanisms of multivesicular body biogenesis
(Project Head
Hoflack, Bernard
)
Patched-dependent regulation of intracellular endocannabinoid trafficking and its function in signalling and metabolism
(Project Heads
Eaton, Suzanne
;
Nadler, André Georg
;
Zerial, Ph.D., Marino
)
Physiological funkction of the cholesterol-interacting, lipid raft-associated plasma membrane protein prominin: from cell biology to human disease
(Project Heads
Corbeil, Denis
;
Huttner, Wieland B.
)
Prominin/membrane-lipid assemblies and their relevance for apical plasma membrane protrusions
(Project Heads
Corbeil, Denis
;
Huttner, Wieland B.
)
Clinical Research Units
Completed projects
Sonic hedgehog signalling in different forms of adrenal hyperplasia
(Applicants
Alexaki, Vasileia Ismini
;
Eaton, Suzanne
)
Major Research Instrumentation
Completed projects
High-resolution fluorescence microscope with photomanipulation
Hightroughput Short Read DNA Sequencing System
Lattice light sheet microscope for fast dual-color long-term imaging
Major Instrumentation Initiatives
Completed projects
New generation laser scanning confocal microscope for multimodal deep tissue and functional imaging
Research Training Groups
Completed projects
GRK 864: Molecular Cell Biology and Bioengineering
(Spokesperson
Reichmann, Heinz
)
Graduate Schools
Completed projects
GSC 97: Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB)
(Spokesperson
Rödel, Gerhard
)
Clusters of Excellence (ExStra)
Current projects
EXC 2068: Physics of Life - The Dynamic Organization of Living Matter (PoL)
(Spokespersons
Campas, Otger
;
Eaton, Suzanne
;
Grill, Stephan Wolfgang
;
Schiessel, Helmut
)
Clusters of Excellence
Completed projects
EXC 168: Regenerative Therapies - From Cells to Tissues to Therapies: Engineering the Cellular Basis of Regeneration
(Spokespersons
Bonifacio, Ph.D., Ezio
;
Brand, Michael
;
Calegari, Ph.D., Federico
;
Tanaka, Ph.D., Elly Margaret
)
NFDI technical and methodological consortia
Current projects
GHGA – German Human Genome-Phenome Archive
(Spokesperson
Stegle, Ph.D., Oliver
)
