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Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Medizinische Fakultät
Klinik und Poliklinik für Neurologie
Address
Venusberg-Campus 1
53127 Bonn
Deutschland
GERiT
This institution in GERiT
53127 Bonn
Projects
Priority Programmes
Completed projects
Molecular Mechanisms in the Regulation of Metabolism and Biological Functions of the ß-Amyloid Precursor Protein
(Applicant
Walter, Ph.D., Jochen
)
Sphingosine-1-phosphate and Alzheimer's disease
(Applicants
van Echten-Deckert, Ph.D., Gerhild
;
Walter, Ph.D., Jochen
)
The role of a4b2 nicotinic acetylcholine receptors in sustained attention: effects in smokers and non-smokers
(Applicant
Wüllner, Ullrich
)
The Role of Phosphorylation in the Regulation of Presenilin Functions
(Applicant
Walter, Ph.D., Jochen
)
Research Grants
Current projects
Molecular and cellular mechanisms in the phosphorylation of the amyloid beta-peptide and their pathophysiological relevance
(Applicant
Walter, Ph.D., Jochen
)
Neuro-aCSis – Bonn Neuroscience Clinician Scientist Program
(Applicant
Petzold, Gabor
)
Completed projects
Ataxin-3-regulierte Gene und Mechanismen der Ataxin-3-vermittelten transkriptionellen Repression
(Applicant
Evert, Bernd
)
Bedeutung funktioneller Domänen von Ataxin-3 beim Transport und Abbau fehlgefalteter Proteine
(Applicant
Wüllner, Ullrich
)
Charakterisierung der Satellitenzell-aktivierenden Mechanismen im Skelettmuskel der C22-Maus, einem Mausmodell für die Charcot-Marie-Tooth 1A-Erkrankung
(Applicant
Reimann, Jens
)
Entwicklung eines Ansatzes zur Therapie neurodegenerativer Erkrankungen auf Basis von RNA-Interferenz am Beispiel der Prionerkrankungen
(Applicants
Pfeifer, Alexander
;
Walter, Ph.D., Jochen
)
Freie Radikale und Degeneration dopaminerger Neurone
(Applicant
Schulz, Jörg Bernhard
)
Freie Radikale und Degeneration dopaminerger Neurone
(Applicant
Klockgether, Thomas
)
Functional consequences of the degeneration of the locus coeruleus-norepinephrine-system in Alzheimer's disease
(Applicant
Fließbach, Klaus
)
Funktion und Regulation von BACE-2
(Applicant
Walter, Ph.D., Jochen
)
Genetic analysis of carotid artery intima-media thickness (IMT)
(Applicants
Klockgether, Thomas
;
Ziegler, Andreas
)
Hypertension-related cognitive deficits and sphingosine-1-phosphate (S1P) - pathophysiology and therapeutic significance
(Applicant
Petzold, Gabor
)
Identification of regional cerebral metabolic covariance patterns specifically associated with the dominant ataxias SCA2, -3 and -6 using FDG-PET uptake measures
(Applicant
Wüllner, Ullrich
)
In vivo Imaging der Blutflussregulation durch Astrozyten in einem Tiermodell der Alzheimer-Erkrankung
(Applicant
Petzold, Gabor
)
Klonierung und Charakterisierung der 5`-Region des SCA3-Gens: Identifizierung des potentiellen Promotor-Bereichs und Analyse der funktionellen Regulation des Gens
(Applicant
Schmitt, Ina
)
Neuronale Repräsentation antizipatorischer versus reaktiver motorischer Kontrolle und Kompensation gestörter Kontrollmechanismen bei Kleinhirnerkrankungen
(Applicants
Boecker, Henning
;
Hermsdörfer, Joachim
)
Nitration of Amyloid beta Alzheimer 's disease
(Applicant
Heneka, Michael Thomas
)
Regulation der Expression von alpha-Synuklein durch Methylierung spezifischer CpG-Motive
(Applicant
Wüllner, Ullrich
)
Role of gamma-secretase in cellular cholesterol metabolism
(Applicant
Oikawa, Ph.D., Naoto
)
Saccade velocity as surrogate marker of severity and progression of spinocerebellare ataxia type 2 (SCA2)
(Applicant
Klockgether, Thomas
)
Research Fellowships
Completed projects
Analyse des myoregenerativen Satellitenzellsystems in normaler und pathologischer humaner Skelettmuskulatur
(Applicant
Reimann, Jens
)
Funktionelle Charakterisierung von aB-Crystallin-Mutanten mittels Transfektionsstudien an humanen und murinen Myoblasten
(Applicant
Fischer, Dirk
)
PPARgamma-induzierte apoptotische Signalwege in C6-Gliomzellen
(Applicant
Grommes, Christian
)
The role of autophagy in the etiopathogenesis of Parkinson's disease
(Applicant
Lachenmayer, Martin Lenard
)
Untersuchung der Beziehung zwischen synaptischer Aktivität und kapillären Blutflussveränderungen im olfaktorischen System von Mäusen in vivo mit Zwei-Photonen-Laser-Scanning-Mikroskopie
(Applicant
Petzold, Gabor
)
Research Units
Current projects
FOR 2795: Synapses under stress: Early events induced by metabolic failure at glutamatergic synapses
(Spokesperson
Rose, Christine R.
)
Functional, structural and metabolic consequences of ionic dysbalance in stroke
(Applicant
Petzold, Gabor
)
Completed projects
Characterization and identification of genes that are regulated by expanded ataxin-3
(Applicant
Klockgether, Thomas
)
FOR 427: Pathogenesis of Spinocerebellar Ataxia Type 3 (SCA3)
(Spokesperson
Klockgether, Thomas
)
Inaktivierung des SCA3-Gens in der Maus
(Applicant
Schmitt, Ina
)
Pathogenesis of spinocerebellas ataxia type 3 (SCA3)
(Applicant
Klockgether, Thomas
)
Clinical Research Units
Completed projects
KFO 177: Innate Immunity in Chronic Neurodegeneration
(Spokesperson
Klockgether, Thomas
)
Local control of inflammation neuronal damage by Peroxisome-profilator-activated receptory (PPARy) in EAE
(Applicant
Klotz, Luisa
)
The role of the CXCR3 chemokine system in Alzheimer´s disease (AD)
(Applicant
Müller, Marcus
)
y-Secretase-dependent processes in microglial functions
(Applicant
Walter, Ph.D., Jochen
)
Collaborative Research Centres
Completed projects
Regulation neuronalen Überlebens durch Stickoxid (NO)
(Project Head
Klockgether, Thomas
)
Sphingolipid metabolism and autophagy in Alzheimer's disease
(Project Head
Walter, Ph.D., Jochen
)
Stickoxid (NO) und neuronaler Zelltod
(Project Heads
Heneka, Michael Thomas
;
Klockgether, Thomas
)
WBP Fellowship
Current projects
Effects of repeated low-intensity ultrasound treatment on alpha-synuclein pathology and motor and behavioral outcome in an alpha-synuclein transgenic mouse model
(Applicant
Purrer, Veronika
)
Major Research Instrumentation
Completed projects
Gerät zur MR-gesteuerten fokussierten Ultraschalltherapie für die intrakranielle Anwendung
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