Universität Münster
Institut für Pharmazeutische und Medizinische Chemie
Address
Corrensstraße 48
48149 Münster
Deutschland
GERiT
This institution in GERiT
48149 Münster
Projects
Research Grants
Current projects
Analysis of the selectivity and promiscuity of ligand binding for fragment-based design
(Applicant
Koch, Oliver
)
Development of fluorinated PET tracers for imaging of sig-2R/TMEM97 in brain tumors
(Applicants
Deuther-Conrad, Winnie
;
Wünsch, Bernhard
)
Development of Small-molecule Inhibitors of Blood Coagulation Factor XIIa as Novel Anticoagulants
(Applicant
Kalinin, Dmitrii
)
Exploration and Exploitation of Secondary Sites of Protein Kinase CK2
(Applicants
Jose, Joachim
;
Niefind, Karsten
)
Novel kappa-Opioid Receptor Agonists for the Treatment of Neuroinflammation
(Applicants
Loser, Karin
;
Wünsch, Bernhard
)
Completed projects
Development of a fluorinated PET tracer for imaging of sigma-2 receptors in the brain and in brain tumors
(Applicants
Brust, Peter
;
Wünsch, Bernhard
)
Development of fluorinated GluN2B-NMDA receptor ligands for positron emission tomography (PET)
(Applicant
Wünsch, Bernhard
)
Development of inhibitors of vascular adhesion protein-1 (VAP-1) as novel antiphlogistic agents
(Applicant
Lehr, Matthias
)
Development of Radiotracers for Imaging of Sigma1-Receptors in the Human Brain
(Applicants
Sabri, Osama
;
Steinbach, Jörg
;
Wünsch, Bernhard
)
Development of Radiotracers for Imaging of Sigma1 Receptors in the Human Brain
(Applicants
Steinbach, Jörg
;
Wünsch, Bernhard
)
Diadenosinpolyphosphate: Synthese eines Analogons und Untersuchung ihrer Wirkungsmechanismen bei der Auslösung einer diabetischen Stoffwechsellage
(Applicant
Verspohl, Eugen J.
)
Die Rolle der Protein-Phosphatase Typ 2C (PP2C) für die neuronale und endotheliale Apoptose
(Applicant
Krieglstein, Josef
)
Die Steuerung von Oszillationen und Insulinsekretion in B-Zellen des Pankreas durch KATP-Kanal unabhängige Mechanismen
(Applicant
Düfer, Martina
)
Dynamic pharmacophores for the discovery of specific modulators of G protein-coupled receptors.
(Applicant
Bermudez, Marcel
)
Entwicklung bicyclischer sigma-Rezeptor-Liganden mit cytotoxischer Aktivität für die Tumortherapie
(Applicants
Bednarski, Patrick
;
Wünsch, Bernhard
)
Entwicklung von Hemmstoffen von Phosphatidylinositol-spezifischen Phospholipasen C als biochemische Tools und potentielle neuartige Arzneistoffe
(Applicant
Lehr, Matthias
)
KORATIN kappa-Opioid-Receptor Agonists for the Treatment of Inflammatory and Itching Skin Diseases
(Applicants
Ständer, Sonja
;
Wünsch, Bernhard
)
Mechanisms of neuroprotection by TGF-ß1
(Applicant
Zhu, Ph.D., Yuan
)
New PET radioligands for imaging of cannabinoid CB2 receptors
(Applicants
Brust, Peter
;
Wünsch, Bernhard
)
Schutz pankreatischer beta-Zellen vor oxidativem Stress durch Modulation der KATP-Kanäle
(Applicant
Düfer, Martina
)
Structure and function of protein histidine phosphatase
(Applicants
Klumpp, Susanne
;
Krieglstein, Josef
)
Targeting metabolic reprogramming and plasticity in cancer stem cells to impact tumor progression and treatment resistance
(Applicant
Wünsch, Bernhard
)
Targeting the therapy resistance factors BAG3 und Bcl-xL in solid tumors
(Applicants
Brunschweiger, Andreas
;
Koch, Oliver
;
Kögel, Donat
)
The role of protein photophase type-2Cin neuronal apoptosis
(Applicant
Klumpp, Susanne
)
Priority Programmes
Current projects
Neural fingerprints as structure and activity-sensitive molecular representations
(Applicants
Koch, Oliver
;
Risse, Benjamin
)
Completed projects
GraBaDrug: Graph-Based Methods for Rational Drug Design
(Applicants
Koch, Oliver
;
Mutzel, Petra
)
Rolle der Protein-Phosphatasen Typ-1 und Typ-2C bei der photo-elektrischen Transduktion
(Applicant
Klumpp, Susanne
)
Heisenberg Grants
Current projects
Structure-based and data-oriented methods for the computational molecular design of bioactive compounds
(Applicant
Koch, Oliver
)
Major Research Instrumentation
Completed projects
600 MHz NMR-Spektrometer
Fluoreszenzbasiertes Durchflusszytometer mit Sortierfunktion und Einzelzellablage
Konfokales Fluoreszenzmikroskop mit TIRF und FRAP Einheit
(U)HPLC-Triple-Quadrupol-Massenspektrometer
Collaborative Research Centres
Completed projects
Inhibitors of matrix metalloproteinases (MMP) for imaging MMP activity in vivo
(Project Heads
Bremer, Christoph
;
Kopka, Klaus
;
Wagner, Stefan
;
Wünsch, Bernhard
)
International Research Training Groups
Completed projects
GRK 1143: Complex Functional Systems in Chemistry: Design, Development and Applications
(Spokesperson
Erker, Gerhard
)
Research Training Groups
Current projects
GRK 2515: Chemical Biology of Ion Channels (Chembion)
(Spokesperson
Wünsch, Bernhard
)
Clusters of Excellence
Completed projects
EXC 1003: Cells in Motion - CiM: Imaging to Understand Cellular Behaviour in Organisms
(Spokesperson
Sorokin, Lydia
)
