Universitätsklinikum Münster
Institut für Physiologie I
Address
Robert-Koch-Straße 27a
48149 Münster
Deutschland
GERiT
This institution in GERiT
48149 Münster
Projects
Research Grants
Current projects
Biomarkers for the ictogenesis of absence seizures – The role of cortical 5-9 Hz oscillations.
(Applicant
Lüttjohann, Ph.D., Annika
)
Investigating the role of NMDA receptor hypofunction in psychosis using neuroimaging across scales and species
(Applicants
Prüß, Harald
;
Stroh, Albrecht
)
Making extinction last: mechanistically understanding and causally probing the role of the ventromedial prefrontal cortex in extinction memory consolidation
(Applicants
Bergmann, Til Ole
;
Kalisch, Raffael
;
Stroh, Albrecht
)
Sex-specific impact of the NPS system on top-down control of fear behavior in mice
(Applicant
Jüngling, Kay
)
Completed projects
Alterations of neuronal excitability in the neocortex associated with glioma invasion
(Applicant
Köhling, Rüdiger
)
Altered functions of ion channels, membrane receptors and neuronal networks associated with thalamocortical dysrhythmia syndrome.
(Applicant
Budde, Thomas
)
Charakterisierung des Erregungsniveaus und der korrelierten Veränderungen der Dichte und Verteilung von Transmitterrezeptoren an überlebendem menschlichen Hirngewebe aus epilepsiechirurgischen Eingriffen
(Applicant
Speckmann, Erwin-Josef
)
Charakterisierung des Erregungsniveaus und der korrelierten Veränderungen der Dichte und Verteilung von Transmitterrezeptoren an überlebendem menschlichen Hirngewebe aus epilepsiechirurgischen Eingriffen
(Applicant
Zilles, Karl
)
Electrophysio Logical an molecular analysis of pace maker channels in a rat model of human absence epilepsy
(Applicant
Budde, Thomas
)
Funktionelle Charakterisierung von intrazellulären Calcium-Transienten in identifizierten thalamischen Neuronen
(Applicant
Budde, Thomas
)
Modulation of dendrodendritic synaptic transmission in the thalamus
(Applicant
Munsch, Thomas
)
Neurophysiologische Grundlagen von kontextuellem Furchtgedächtnis in amygdalo-hippocampalen Schaltkreisen
(Applicant
Pape, Hans-Christian
)
Optogentic control of epileptic seizures in a network mapped by simultaneous calcium recordings and fMRI
(Applicants
Budde, Thomas
;
Faber, Cornelius
)
Rolle intrathalamischer Neurone für Spike-Wave-Entladungen in einem genetischen Rattenmodell für Absence Epilepsie
(Applicant
Pape, Hans-Christian
)
Speziesübergreifender Vergleich pathophysiologischer Mechanismen bei Nagermodellen der menschlichen Absence-Epilepsie unter besonderer Berücksichtigung von thalamischen Interneuronen.
(Applicant
Budde, Thomas
)
Veränderte Expression von Schrittmacherkanälen in einem Rattenmodell der menschlichen Absence-Epilepsie
(Applicant
Budde, Thomas
)
Veränderungen der neuronalen Erregbarkeit in der Hirnrinde bei Gliominvasion
(Applicant
Paulus, Werner
)
Veränderungen der neuronalen Erregbarkeit in der Hirnrinde bei Gliominvasion
(Applicant
Speckmann, Erwin-Josef
)
Zelltyp- und Isoform-spezifische Analyse der Funktion und Dysfunktion von Schrittmacherkanälen im Thalamus
(Applicant
Budde, Thomas
)
Collaborative Research Centres
Completed projects
Deciphering the role of Yap1 in the life-long homeostasis of hippocampal neural stem cells
(Project Heads
Berninger, Benedikt
;
Stroh, Albrecht
;
Tiwari, Vijay
)
Making extinction last: mechanistically understanding and causally probing the role of the ventromedial prefrontal cortex in extinction memory consolidation
(Project Heads
Bergmann, Til Ole
;
Kalisch, Raffael
;
Stroh, Albrecht
)
Mechanismen der synaptischen Integration in der Amygdala
(Project Head
Pape, Hans-Christian
)
Molekulare Mechanismen konditionierter Furcht: Expression und Wirkung von Neuropeptiden
(Project Heads
Pape, Hans-Christian
;
Stork, Oliver
)
Regulation of neural excitability and neural-network function in resilience - a multimodal and (back-) translational approach
(Project Heads
Groppa, Sergiu
;
Nitsch, Robert
;
Stroh, Albrecht
;
Vogt, Johannes
)
SFB-Sekretariat
(Project Head
Pape, Hans-Christian
)
SFB-Sekretariat
(Project Head
Pape, Hans-Christian
)
CRC/Transregios
Current projects
Characterization of life event-triggered inflection signals and emotion regulation in a Cacna1c mouse model
(Project Heads
Bernhardt, Ph.D., Nadine
;
Jüngling, Kay
)
Impact of chronobiologic modulation on behavioural rhythms, neuroplasticity and immune-metabolic parameters
(Project Heads
Culmsee, Carsten
;
Jüngling, Kay
)
Completed projects
Cell type-specificity of endocannabinoid signaling in amygdala-BNST projections regulating sustained fear
(Project Heads
Lutz, Beat
;
Pape, Hans-Christian
)
Central Tasks of the Transregional Collaborative Research Centre
(Project Head
Pape, Hans-Christian
)
Contribution of CRF and 5-HT in the antero-dorsal BNST on phasic and sustained fear in freely behaving mice
(Project Head
Seidenbecher, Thomas
)
Distinct circuits of the extended amygdala regulating fear generalization and extinction
(Project Head
Pape, Hans-Christian
)
Impact of the Neuropeptide S system and NPS-receptor polymorphisms on fear and anxiety
(Project Head
Jüngling, Kay
)
Interaktionen in amygdala-entorhinal-corticalen Schaltkreisen bei tierexperimentellen Modellen der Temporallappen-Epilepsie
(Project Heads
Albrecht, Doris
;
Pape, Hans-Christian
)
Neurophysiologische Korrelate anfallsbezogener Einflüsse auf Furchtverhalten und Furchtgedächtnis in amygdalo-hippocampalen Schaltkreisen
(Project Heads
Pape, Hans-Christian
;
Seidenbecher, Thomas
)
Rebalancing cortical neuronal hyperactivity as a new treatment strategy in Neuroinflammation
(Project Heads
Ellwardt, Erik
;
Stroh, Albrecht
;
Zipp, Frauke
)
Synaptic networks in the human lateral amygdala: contribution to the generation and maintenance of epileptiform activity
(Project Heads
Pape, Hans-Christian
;
Speckmann, Erwin-Josef
)
The BDNF system as mediator for stress impaired fear acquisition, extinction and late fear
(Project Heads
Andreatta, Marta
;
Lange, Maren Denise
)
The role of the kallikrein-kinin system to functional and structural impairment of network activity in multiple sclerosis
(Project Heads
Budde, Thomas
;
Göbel, Kerstin
;
Meuth, Sven G.
;
Pape, Hans-Christian
)
TRR 58: Fear, Anxiety, Anxiety Disorders
(Spokesperson
Pape, Hans-Christian
)
Research Units
Completed projects
K2P-Kanäle - vom Molekül zur Physiologie und Pathophysiologie
(Applicant
Daut, Jürgen
)
Modulation, Funktion und neuroprotektives Potential von TASK- und TRESK-Kanälen im zentralen Nervensystem
(Applicants
Budde, Thomas
;
Meuth, Sven G.
)
Major Research Instrumentation
Completed projects
2-Photonen Mikroskopie Plattform: 2-Photonenmikroskop für in vivo Anwendungen inkl. Laserpaket und "virtual reality"-Zubehör
2-Photonen Mikroskopie Plattform: 2-Photonenmikroskop zur hochauflösenden Mikroskopie inkl. Laserpaket
2-Photonen Mikroskopie Plattform: Aufrechtes 2-Photonenmikroskop inkl. Laserpaket
Priority Programmes
Completed projects
Causal probing of slow oscillations in rodent models of Alzheimer´s disease: combining optogenetics with multimodal opto-acousto-magnetic imaging
(Applicants
Stroh, Albrecht
;
Westmeyer, Gil
;
Yu, Ph.D., Xin
)
Research Training Groups
Current projects
GRK 2515: Chemical Biology of Ion Channels (Chembion)
(Spokesperson
Wünsch, Bernhard
)
Completed projects
GRK 253: Biological Basis of Central Nervous System Diseases
(Spokesperson
Reiser, Georg
)
Clusters of Excellence
Completed projects
EXC 1003: Cells in Motion - CiM: Imaging to Understand Cellular Behaviour in Organisms
(Spokesperson
Sorokin, Lydia
)
