Heinrich-Heine-Universität Düsseldorf
Institut für Biochemie
Lehrstuhl für Biochemie I
Address
Universitätsstraße 1
40225 Düsseldorf
Deutschland
GERiT
This institution in GERiT
40225 Düsseldorf
Projects
Research Grants
Current projects
Cardiolipins: elucidating their diversity, biosynthesis and role in the membrane adaptation of pathogens towards environmental stress.
(Applicant
Exterkate, Marten
)
Cross-talk between energy supply and drug translocation in the ABC transporter Pdr5
(Applicants
Schmitt, Lutz
;
Wagner, Richard
)
Structure and dynamics of the Pel exopolysaccharide secretion machinery of Pseudomonas aeruginosa
(Applicant
Kedrov, Alexej A.
)
Completed projects
Analyse der molekularen Dynamik der Nukleotid-bindenden Domäne des ABC-Transporters HlyB mittels NMR
(Applicants
Dötsch, Volker
;
Schmitt, Lutz
)
Auswirkungen mitochondrialer Dysfunktion in hämatopoietischen Zellen: Störung des Energie- und Eisenstoffwechsels und Entstehung genetischer Instabilität
(Applicant
Gattermann, Norbert
)
Funktion des scERV1 und des homologen huALR Gens für die Aktivität und Biogenese der Mitochondrien in Hefe und menschlichen Zellen
(Applicant
Hofhaus, Götz
)
Inhibitoren der Peptidyl-Prolyl-cis/trans-lsomerase auf der Basis von Übergangszustandsanaloga
(Applicant
Braun, Manfred
)
Maturation and secretion of nisin A from Lactococcus lactis
(Applicant
Schmitt, Lutz
)
Maturation and secretion of nisin A from Lactococcus lactis
(Applicant
Schmitt, Lutz
)
Membrane protein folding in the crowded environment
(Applicant
Kedrov, Alexej A.
)
Molekulare Mechanismen tierischer Anpassung
(Applicant
Grieshaber, Manfred K.
)
Molekulare Struktur des mitochondrialen Atmungsketten-Komplex I
(Applicant
Weiss, Hanns
)
Neurospora Genomprojekt
(Applicant
Schulte, Ulrich
)
Photoaktivierbare Proteine
(Applicant
Schmitt, Lutz
)
Single-molecule functional analysis of the yeast ABC-transporter Pdr5p
(Applicants
Schmitt, Lutz
;
Volkmer, Andreas
)
Structural and functional principles of low potassium signaling and the integration of nutrient sensing and adaptation in Arabidopsis
(Applicants
Kudla, Jörg
;
Schmitt, Lutz
)
Struktur und Evolution der Opindehydrogenasen
(Applicant
Grieshaber, Manfred K.
)
Systemische und molekulare Mechanismen tierischer Anpassung
(Applicant
Grieshaber, Manfred K.
)
Emmy Noether Independent Junior Research Groups
Completed projects
Struktur, Dynamik und Funktion von ABC-Transportern
(Applicant
Schmitt, Lutz
)
Priority Programmes
Completed projects
Molecular interaction and high-resolution X-ray structures of the subunits of the osmoregulated ABC-transporter OpuA from B. subtillis
(Applicant
Schmitt, Lutz
)
Heisenberg Fellowships
Completed projects
Biochemie
(Applicant
Schmitt, Lutz
)
Clinical Research Units
Completed projects
Quantitative Struktur-Aktivitätsanalysen hepatobiliärer Transport-Systeme und deren pharmakologische Relevanz
(Applicant
Schmitt, Lutz
)
Collaborative Research Centres
Current projects
Links between mitochondrial energy metabolism and intracellular stress response pathways
(Project Heads
Reichert, Andreas
;
Schmitt, Lutz
)
Sensors for monitoring microbial metabolism and its regulation: structural and imaging approaches
(Project Heads
Frommer, Wolf-Bernd
;
Smits, Sander
;
Weidtkamp-Peters, Stefanie
)
Completed projects
Bedeutung des ALR-Proteins bei der Leberregeneration
(Project Heads
Hofhaus, Götz
;
Lisowsky, Thomas
)
Central Tasks
(Project Head
Schmitt, Lutz
)
Interaction network and regulation of the human ABC transporter MDR3
(Project Head
Schmitt, Lutz
)
In vitro characterization of ABC-transporters in human liver
(Project Head
Schmitt, Lutz
)
Membrane translocation and chaperone-dependent folding of the lipase A of Pseudomonas aeruginosa
(Project Head
Kedrov, Alexej A.
)
Protein Transport Across Biological Membranes - the HlyB/HlyA System from E.coli
(Project Head
Schmitt, Lutz
)
SFB 1208: Identity and Dynamics of Membrane Systems - from Molecules to Cellular Functions
(Spokesperson
Schmitt, Lutz
)
The hemolysin A secretion machinery from E. coli
(Project Head
Schmitt, Lutz
)
Major Research Instrumentation
Completed projects
Kleinwinkelröntgenstreuanlage
Nanopipettingrobot and Crystalisationhotel with UV-/VIS Camera
Röntgendiffraktometer
Core Facilities
Current projects
Center for Structural Studies
Major Instrumentation Initiatives
Completed projects
DNP-enhanced solid-state NMR spectroscopy
(Applicant
Heise, Henrike
)
Research Training Groups
Current projects
GRK 2158: Natural products and natural product analogs against therapy-resistant tumors and microorganisms: new lead structures and modes of action
(Spokesperson
Gohlke, Holger
)
Completed projects
GRK 57: Molecular Physiology: Metabolism and Energy Transformation
(Spokesperson
Grieshaber, Manfred K.
)
GRK 320: Pathological Processes of the Nervous System: From Gene to Behavior
(Spokesperson
Reifenberger, Ph.D., Guido
)
GRK 541: Protein Function at the Atomic Level
(Spokesperson
Buckel, Wolfgang
)
Clusters of Excellence
Completed projects
EXC 1028: Cluster of Excellence on Plant Sciences (CEPLAS) - From Complex Traits towards Synthetic Modules
(Spokesperson
Weber, Andreas P.M.
)
