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Institution
Universitätsklinikum Aachen, AÖR
Klinik für Gastroenterologie, Stoffwechselerkrankungen und
Internistische Intensivmedizin (Med. Klinik III)
Address
Pauwelsstraße 30
52074 Aachen
Deutschland
GERiT
This institution in GERiT
52074 Aachen
Projects
Research Grants
Current projects
Mechanisms controlling pro-inflammatory mast cell functions and implications for chronic liver disease and cancer
(Applicants
Huber, Michael
;
Liedtke, Christian
;
Meurer, Steffen Klaus
;
Weiskirchen, Ralf
)
Ultrasound-controlled Cancer Immunotherapy using DNA Nanostructures
(Applicant
Herrmann, Andreas
)
Completed projects
Antigen-spezifische Erkennung von intestinalen Kommensalen durch regulatorische und Effektor- T Zellen
(Applicant
Sellge, Gernot
)
Charakterisierung der durch chemotaktische Moleküle vermittelten intrahepatischen Immunregulation im Rahmen der murinen Leberfibrogenese
(Applicant
Wasmuth, Hermann E.
)
Einfluss von Chaperonen und oxidativem Stress auf Mallorykörperentstehung
(Applicant
Strnad, Pavel
)
Modulation of Peritoneal Macrophage Differentiation and Function for Prophylaxis of Complications in Decompensated Cirrhosis
(Applicant
Bruns, Tony
)
Molekulare Analyse zur Rolle von Cyclin E für den G0/S-Phase Zellzyklusübergang und die maligne Transformation der Hepatozyten
(Applicant
Liedtke, Christian
)
Platelets as initiators and mediators of liver fibrosis
(Applicant
Sahin, Hacer
)
Significance of IL-6 and TNF-alpha for regeneration matrix remodelling after toxic liver damage and partial hepatectomy
(Applicant
Siewert, Elmar
)
The effect of cell specific deletion of endoglin (CD105), a transmembrane auxiliary receptor for TGF-beta, on murine models of liver fibrosis
(Applicant
Scholten, David
)
The impact of Cyclin E1 in alcohol-induced organ disease and carcinogenesis within the Gut-liver axis
(Applicant
Nevzorova, Ph.D., Yulia
)
Therapy of Hepatocellular Carcinoma through targeted inhibition of the cell cycle mediators Cyclin E1 and Cdk2 in mouse models
(Applicant
Liedtke, Christian
)
The role of keratins in the liver
(Applicant
Strnad, Pavel
)
The role of the PNPLA3 I148M polymorphism for adipose tissue function in health and disease
(Applicant
Hatting, Maximilian
)
Thrombozyten und deren assoziierte Chemokine als Initiatoren und Modulatoren der biliären Entzündung
(Applicant
Wasmuth, Hermann E.
)
Translational studies of the induction and functional role of Th2 polarized CD4+ T-cells in chronic liver damage and hepatic fibrogenesis
(Applicant
Zimmermann, Henning
)
Ultrasound-guided intrahepatic release of therapeutic nucleic acids for treatment of inflammatory liver disease
(Applicant
Bartneck, Ph.D., Matthias
)
Untersuchungen zur Funktion und Regulation der Gallensäuren ß-Glucosidase beim Menschen
(Applicant
Matern, Siegfried
)
Research Fellowships
Completed projects
Charakterisierung Hepatitis C spezifischer CD8+ T-Zellen aus perpherem Blut und der Leber mittels Multicolor Flow Cytometry und Microarray RNA Transkriptionsanalyse
(Applicant
Kroy, Daniela
)
Die Bedeutung der zellulären Immunität bei der Shigellose
(Applicant
Sellge, Gernot
)
Human Cytomegalovirus Infection of Human Hepatic Sinusoidal Endothelial Cells Modulates T Cell Recruitment into the Liver
(Applicant
Bruns, Tony
)
Restoring intestinal barrier function in obesity and diabetes.
(Applicant
Schneider, Kai Markus
)
The impact of the CXC chemokine CXCL13 mediated B lymphocyte recruitment on the development and progression of hepatocellular carcinoma
(Applicant
Berres, Marie-Luise
)
The role of Cdc-like kinase 2 (Clk2) in hepatic glucose and lipid metabolism
(Applicant
Hatting, Maximilian
)
Independent Junior Research Groups
Completed projects
Genesis and consequences of inborn and acquired alterations of hepatocellular keratin architecture
(Applicant
Strnad, Pavel
)
Priority Programmes
Completed projects
Consequences of desmoglein 2 loss for organization and function of intestinal epithelial junctions
(Applicant
Strnad, Pavel
)
Relevance of ferroptosis and its therapeutic potential during acute liver injury and hepatocellular carcinoma formation
(Applicant
Otto, Tobias
)
Heisenberg Grants
Current projects
Epithelial biology of digestive disorders
(Applicant
Strnad, Pavel
)
CRC/Transregios
Completed projects
Defining HGF/c-Met dependent diagnostic markers and novel therapeutic targets in NASH-development
(Project Heads
Kroy, Daniela
;
Streetz, Konrad Ludwig
;
Zimmermann, Henning
)
Iron and a1-antitrypsin accumulation as hepatocellular initiators of liver fibrosis
(Project Head
Strnad, Pavel
)
Targeting MIF family proteins in liver fibrosis: Mechanisms and translational approaches
(Project Heads
Bernhagen, Jürgen
;
Berres, Marie-Luise
)
The CXCR3/CXCL9 chemokine system as an antifibrotic target in murine liver fibrosis
(Project Head
Wasmuth, Hermann E.
)
The effect of cell-specific deletion of Endoglin (CD105), a transmembrane auxiliary receptor for TGF-ß, on murine models of liver fibrosis
(Project Head
Scholten, David
)
Treatment of liver fibrosis through inhibition of the Cyclin E1/Cdk2 kinase complex
(Project Heads
Liedtke, Christian
;
Nevzorova, Ph.D., Yulia
;
Trautwein, Christian
)
Collaborative Research Centres
Current projects
A population-based approach to diet-microbiota interactions that drive liver diseases
(Project Head
Schneider, Carolin Victoria
)
Dendritic cells as cellular targets of gut-liver communication regulating therapy induced HCC as well as CRC liver metastasis regression
(Project Head
Berres, Marie-Luise
)
Elucidating microbiota-dependent and independent functions of inflammasome-mediated innate immunity during hepatocellular carcinoma development
(Project Head
Schneider, Kai Markus
)
Functional impact of risk factors for disease progression within the gut-liver axis
(Project Heads
Candels, Lena
;
Trautwein, Christian
)
Integrated Research Training Group ‘Gut-Liver Axis’
(Project Heads
Hornef, Mathias Walter
;
Liedtke, Christian
)
Peritoneal immune states link gut and liver pathology in cirrhosis
(Project Heads
Bruns, Tony
;
Vehreschild, Maria J G T
)
The role of proteotoxic stress in the gut-liver axis
(Project Heads
Güldiken, Nurdan
;
Strnad, Pavel
)
Tissue regeneration as a critical component of gut‐liver homeostasis
(Project Head
Liedtke, Christian
)
Completed projects
Multi-functional microgels targeted towards inflammatory bowel disease (IBD)
(Project Heads
Elling, Lothar
;
Kühne, Alexander
;
Sellge, Gernot
;
Strnad, Pavel
;
Trautwein, Christian
)
The Role of TNF and Fas-mediated signalling in models of inflammatory liver injury
(Project Heads
Liedtke, Christian
;
Trautwein, Christian
)
WBP Fellowship
Completed projects
HSD17B13 and MARC1 - Understanding genetic protection from non-alcoholic fatty liver disease
(Applicant
Schneider, Carolin Victoria
)
The Role of Antimicrobial Peptides in Primary Sclerosing Cholangitis
(Applicant
Spivak, Igor
)
Clinical Trials
Completed projects
Covered transjugular intrahepatic portosystemic stent shunt versus optimezed medical treatment for the secondary prevention of variceal bleeding in cirrhosis
(Applicant
Sauerbruch, Tilman
)
Research Training Groups
Current projects
GRK 2375: Tumor-Targeted Drug Delivery
(Spokesperson
Kiessling, Fabian
)
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