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TRR 77:  Liver Cancer - From Molecular Pathogenesis to Targeted Therapies

Subject Area Medicine
Biology
Term from 2010 to 2014
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 88491948
 
Hepatocellular carcinoma (HCC) is one of the most frequent and dismal malignancies with so far limited therapeutic options, but also an ideal model system for tumour research as the most relevant paradigm for virus-induced and inflammation-mediated cancer. Recent progress has demonstrated the feasibility of translating basic biomedical research findings into HCC therapy.
The main aim of the Transregional Collaborative Research Centre is to gain a profound understanding of the molecular basis of human hepatocarcinogenesis beginning with its initiation from chronic liver disease to its progression into metastatic cancer, its functional dissection and the identification of novel preventive, diagnostic and therapeutic approaches by concentrating on three main goals: (1) to understand general and specific mechanisms of chronic liver diseases (specifically chronic viral infection and inflammation-mediated processes) that predispose to or initiate the liver cancer and may lead to new preventive strategies (Research Area A); (2) to identify and functionally characterise key molecular events that promote or sustain liver cancer and thus may serve as markers for tumour relevant functions or that may unravel promising mechanisms and targets for future therapeutic intervention (Research Area B); (3) to functionally dissect specific tumour-relevant mechanisms already identified in previous research, to explore modes of translation and improve tumour targeting (Research Area C).
The Transregional Collaborative Research Centre is based on a wide, well-annotated collection of human tissue, cell lines and mouse models serving as a common platform for all research groups. For the first time in liver cancer research this platform allows to compare complex biological data of human tissues, cells and murine models and to link them with functional in vitro and in vivo analysis.
The consortium focusses on biomedical basic research and preclinic research and at is both sites, Hannover as well as Heidelberg integrated in an excellent liver and tumour research surrounding with also international networking activities. This is why it forms an important international focal point, even in the long run, for further innovative stages in the field of liver tumour research. New preventive strategies, specific therapies and predictive as well as prognostic diagnostics will be relevant spin-offs.
DFG Programme CRC/Transregios

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