GRK 1505:  Analysis and Simulation of Electric Interactions between Implants and Biosystems - welisa

• Subject Area: Electrical Engineering and Information Technology
• Term: from 2008 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 55641801

• Final Report Year: 2018

Final Report Abstract

Trotz zahlreicher Erfolge mit implantierten technischen Systemen zur Unterstützung von Körperfunktionen, die durch Krankheit, Unfall oder Alter eingeschränkt wurden, besteht ein weit gespannter Forschungsbedarf mit den Zielstellungen verbesserter Funktion, höherer Verträglichkeit und längerer Haltbarkeit von Implantaten. Ein erheblicher Teil der daraus entstehenden Fragestellungen ist direkt mit einem möglichst tiefgehenden Verständnis der Prozesse an der Grenzfläche zwischen Implantat und dem umgebenden Gewebe verbunden. Dies setzt seinerseits eine detaillierte Kenntnis der dort stattfindenden elektrochemischen Vorgänge, gegebenenfalls beeinflusst durch extern angelegte elektromagnetische Felder, voraus. Die präzise modellhafte Beschreibung der Prozesse an der Grenzfläche zwischen Implantat und dem umgebenden Gewebe sowohl aus biologisch-medizinischer als auch aus physikalisch-elektrotechnischer und biophysikalisch-elektrochemischer Sicht, stellte die zentrale Forschungsidee des Graduiertenkollegs welisa dar. Zur Untersuchung dieser Prozesse wurden experimentelle Analysen zur Adhäsion und Proliferation humaner Zellen, biophysikalische Experimente zur elektrischen Kopplung von Nervenzellnetzwerken mit Sensorchips, Experimente zum Einfluss elektromagnetischer Felder auf Bakterien und humane Zellen sowie elektrische Feldberechnungen und thermodynamische Simulationen auf unterschiedlichen Größenskalen durchgeführt. Zur Beschreibung der Prozesse wurden innovative, automatisierte, statistische und systembiologische Methoden entwickelt. Zu den wichtigsten Erfolgen und Innovationen gehören numerische Volumenleitermodelle für Gehirn, Hüfte und Cochlea, Methoden zur Unsicherheitsquantifizierung, neue Biokeramiken und Verbundstoffe, ein neuartiges elektrostimulatives Hüftimplantat, automatische Aktin-Filament-Quantifizierung zur Analyse von Zelladhäsion und Topographieeinfluss, Definition von Bedingungen für das Wachstum von Biofilmen auf Implantaten sowie ein System zur Tiefen Hirnstimulation zur Langzeitstimulation in Ratten bei freier Beweglichkeit. Die gewonnenen Erkenntnisse haben direkten Bezug zur Analyse der elektrischen Wechselwirkungen zwischen Implantaten und dem Biosystem und somit zur Optimierung der Tiefen Hirnstimulation, von Cochlea-Implantaten sowie elektrostimulierenden Implantatsystemen zur Knochenregeneration für die spätere klinische Anwendung. Die Fachbereiche Medizin, Materialwissenschaft, Biophysik, Zellbiologie, Elektrotechnik, Informatik und Mathematik haben dabei eng zusammengewirkt. Die Doktorandinnen und Doktoranden waren sowohl in fachlicher wie in methodischer Sicht besonders in interdisziplinär ausgerichtete Arbeiten eingebunden. Zu ihrer Weiterqualifizierung wurden Lehrveranstaltungen, teils in englischer Sprache, individuell festgelegt. Mit seiner Forschung stärkte das GRK die Profillinien „Leben, Licht und Materie“ sowie „Altern des Individuums und der Gesellschaft“ der Universität Rostock.

Publications

• 2008. Dichtelement und Kontaktbuchse für medizinisches Implantat. Z: EP 19747768 (A1)
  Rebentisch, R.
  
• 2008. Federkontakt und Kontaktbuchse für einen Elektrodenleitungsstecker. AZ: EP 1974767 (A1)
  Rebentisch, R.
  
• 2008. Kontaktanordnung, Kontaktbaugruppe, implantierbare Vorrichtung und Elektrodenleitung. AZ: EP 1923967 (A3)
  Rebentisch, R.
  
• 2008. Novel Rapid Prototyping Processes – Building Movable Parts, In: Bartolo PJ et al. (Eds.), Virtual and Rapid Manufacturing, Advanced Research in Virtual and Rapid Prototyping. London: Taylor & Francis Group, pp. 665–666. ISBN: 978-0-415-41602-3
  Ansorge, F., Badstuebner, K., Reichel, H.
  
• 2009. 3D-Simulation of Action Potential Propagation in a Squid Giant Axon. COMSOL Conference, Bangalore, India, 5 pages
  Appali, R., Petersen, S., Gimsa, J. and Van Rienen, U.
  
• 2009. Classical Models of the Interface between an Electrode and Electrolyte. COMSOL Conference, Milan, Italy, 4 pages
  Gongadze, E., Petersen, S., Beck, U. and van Rienen, U.
  
• 2009. Definiert mikrostrukturierte Titanoberflächen und deren Einfluss auf die Organisation des Aktinzytoskeletts von humanen Osteoblasten. Deutsche Gesellschaft für Biomaterialien (DGBM), BIOmaterialien 10 (3/4), Tübingen, Germany, p.129. ISSN: 1616-0177
  Matschegewski, C., Staehlke, S., Loeffler, R., Kern, D., Beck, U., Lange, R. and Nebe, J.B.
  
• 2009. iCAMS: An FPGA-Based System for the REAL-Time Monitoring of the Activity of in-vitro Cells. 32nd Annual Conference on Artificial Intelligence, pp. 1-4
  Lueder, M., Salomon, R. and Reimer, T.
  
• 2009. Impedance spectroscopy and cell constant of the electrodes for deep brain stimulation. COMSOL Conference, Milan, Italy, 6 pages
  Vinter, E., Petersen, S., Gimsa, J. and van Rienen, U.
  
• 2009. Material properties of Titanium surfaces with regular geometry and their influence on osteoblast behaviour. ESB, Lausanne, Switzerland
  Lange, R., Elter, P., Matschegewski, C., Weidmann, A., Löffler, R., Fleischer, M., Nebe, J.B., Kern, D. and Beck, U.
  
• 2009. Quantification of actin filament organization by estimating graph structures in confocal microscopic images. International Federation for Medical and Biological Engineering Proceedings, 25 (4), pp. 1932-1935. ISSN: 1680-0737
  Birkholz, H., Matschegewski, C., Nebe, J.B. and Engel, K.
  
• 2009. Sensitivity of Osteoblasts to Topographical and Chemical Features of Metal Implants. ICMAT, Singapore
  Nebe, J.B., Jesswein, H., Weidmann, A., Finke, B., Matschegewski, C., Lange, R., Beck, U. and Schroeder, K.
  
• 2009. Solar Concentrating Systems Using Small Mirror Arrays. Journal of Solar Energy Engineering, 132(1), pp. 1-4
  Göttsche, Joachim; Hoffschmidt, Bernhard; Schmitz, Stefan; Sauerborn, Markus; Buck, Reiner; Teufel, Edgar; Badstübner, Kathrin; Ifland, David; Rebholz, Christian
  
• 2009. Thin membrane modelling for the electrical stimulation of auditory nerve. COMSOL Conference, Milano, Italy, pp. 14-16
  Grünbaum, A., Petersen, S., Pau, H. W. and van Rienen, U.
  
• 2009. Time dependent activation of intracellular signaling proteins in osteoblasts on microstructured titanium surfaces. Eur J Cell Biol ;88, 32. ISSN: 0171-9335
  Matschegewski, C., Weidmann, A., Lange, R., Loeffler, R., Beck, U., Kern, D. and Nebe, J.B.
  
• 2009. Time dependent adhesion of vital human osteoblasts on positively charged plasma polymer coated surfaces. 3rd International Symposium “Interface Biology of Implants” (IBI) ISSN 1616 0177 BIOmaterialien 10 (S1), p. 75, Rostock, Germany
  Jesswein, H., Finke, B., Lange, R., Staehlke, S., Beck, U., Gimsa, J., Schroeder, K. and Nebe, J.B.
  
• 2009. Titanium Surfaces Structured with Regular Geometry – Material and Cellular Biological Investigations. 13th European Conference on Applications of Surface and Interface Analysis (ECASIA), Antalya, Turkey
  Lange, R., Elter, P., Biala, K. Matschegewski, C., Staehlke, S., Loeffler, R., Fleischer, M., Nebe, J.B., Kern, D. and Beck, U.
  
• 2010. A comparison of Hodgkin-Huxley and soliton neural theories. Advances in Radio Science, 8, pp. 75-79
  Appali, R.; Petersen, S.; van Rienen, U.
  
• 2010. A hybrid approach to quantify lamination of the cerebral cortex. International Journal of Nonlinear Sciences and Numerical Simulation, 11(5), pp. 363–370
  Schmitt, O.; Birkholz, H.
  
• 2010. A novel modular device for 3-D bone cell culture and non-destructive cell analysis. Acta Biomaterialia, 6, pp. 3798-3807
  Kunz, Friederike; Bergemann, Claudia; Klinkenberg, Ernst-Dieter; Weidmann, Arne; Lange, Regina; Beck, Ulrich; Nebe, J. Barbara
  
• 2010. Aktuatorik und Sensorik für die Überwachung metabolischer Parameter in 3D Zellkultursystemen. 15. Heiligenstädter Kolloquium, Heilbad Heiligenstadt
  Bonk, S. M., Buehler, S.M., Stubbe, M., Baumann, W. und Gimsa, J.
  
• 2010. An Electrical Double Layer Model with Spatial Variation of the Permittivity. International Symposium on Electromagnetic Theory (EMTS), Berlin, Germany, pp. 540-543. ISBN: 978-1-4244-5154-8
  Gongadze, E., Iglič, A., Petersen, S. and van Rienen, U.
  
• 2010. Analysis and Simulation of Electrical Interactions of Implants with Biosystems. Biomedizinische Technik/Biomedical Engineering, 55 (1), pp. 167–170
  van Rienen, U., Appali, R., Bader, R., Baumann, W., Beck, U., Behrend, D., Benecke, R., Biala, K., Birkholz, H., Burkel, E., Engel, G., Gimsa, J., Gimsa, U., Gongadze, E., Grünbaum, A., Haba, Y., Liese, F., Liu, B., Lueder,M.,Matschegewski,C., Mittelmeier, W., Mix, E., Nebe, J.B., Nowak, K.A., Pahnke, J., Pau, H.W., Pauleweit, S., Petersen, S., Polnick, S., Reimer, T., Rott, G., Salomon, R., Vinter, E., Weihe, T. and Wolkenhauer, O.
  
• 2010. Automatische Auswertung von Aktinfilament-Strukturen in konfokal-mikroskopischen Bildern. Biomedizinische Technik/ Biomedical Engineering, 55 (1), pp.233-236
  Birkholz, H., Labahn, R., Engel, K. and Nebe, J. B.
  
• 2010. Cell architecture on plasmafunctionalized, structured metal surfaces. Proceeding of the European Society for Biomaterials 2010, CD abstract no. H 3492, Tampere, Finland
  Rebl, H., Finke, B., Matschegewski, C., Staehlke, S., Lange, R., Kern, D.P., Beck, U., Schroeder, K. and Nebe, J.B.
  
• 2010. Cell architecture-cell function dependencies on titanium arrays with regular geometry. Biomaterials, 31(22), pp. 5729-5740
  Matschegewski, Claudia; Staehlke, Susanne; Loeffler, Ronny; Lange, Regina; Chai, Feng; Kern, Dieter P.; Beck, Ulrich; Nebe, Barbara J.
  
• 2010. Challenges in Bio-Electromagnetic Modeling. URSI International Symposium on Electromagnetic Theory (EMTS), Berlin, Germany, IEEE, pp. 344-347. ISBN: 978-1-4244-5154-8
  Potratz, C., Petersen, S., Grünbaum, A. and van Rienen, U.
  
• 2010. Describing electrostatic attraction between negatively charged mediated by organic counter-ions of different length. Biochemistry, Gordon Research, Biddeford (ME), USA
  Weihe, T., Perutkova, S., Kralj-Iglic, V., Elter, P., Iglic, A. and Gimsa, J.
  
• 2010. Dielectric properties of porous calcium titanate. Biomedizinische Technik/Biomedical Engineering, 55 (1), pp. 179-181
  Rott, G.A., Zhang, F., Haba, Y. and Burkel, E.
  
• 2010. Dielectric Spectroscopy and Microstructure of Sintered Calcium Titanate (CaTiO3) Samples With Different Porosities. Material Science and Engineering, Darmstadt, Germany
  Rott, G.A., Zhang, F., Haba, Y., Kroeger, W. and Burkel, E.
  
• 2010. Ein 3D-CAD-Modell der menschlichen Cochlea für elektromagnetische Simulationen (A 3D-CAD-Model of the Human Cochlea for Electromagnetic Studies). Biomedizinische Technik/ Biomedical Engineering, 55 (1), pp. 231-233
  Grünbaum, A., van Rienen, U. and Pau, H.W.
  
• 2010. Einfluss der Anisotropie der Leitfähigkeit von Hirngewebe auf die elektrische Feldverteilung um Elektroden zur tiefen Hirnstimulation. (Influence of the anisotropic conductivity of the brain tissue on the electric field distribution around electrodes for deep brain stimulation). Biomedizinische Technik/Biomedical Engineering, 55(1), pp. 234-237
  Vinter, E., Petersen, S. and Van Rienen, U.
  
• 2010. Elektrische Doppelschicht und strukturierte Titan Implantate (Electrical Double Layer and structured titanium implants). Biomedizinische Technik/Biomedical Engineering, 55 (1), pp.171-174
  Gongadze, E., Petersen, S., Iglič, A. and Van Rienen, U.
  
• 2010. Ermittlung elektrischer Materialeigenschaften von humanen Femurköpfen für den Einsatz elektrostimulierender Knochenimplantate. 13. Symposium Maritime Elektrotechnik, Elektronik und Informationstechnik Rostock Deutschland, pp. 61-66
  Haba, Y., Stüpmann, F., Kroeger, W., Bader, R., Kluess, D., Souffrant, R., Mittelmeier, W. and Ewald, H.
  
• 2010. Ermittlung elektrischer und mechanischer Materialparameter am humanen Femurkopf (Determination of electrical and mechanical material parameters on the human femoral head). Biomedizinische Technik/Biomedical Engineering, 55, pp. 182-185
  Haba, Y., Schiebenhoefer, A. K., Kroeger, W., Ewald, H., Souffrant, R., Kluess, D., Mittelmeier, W. and Bader, R.
  
• 2010. Excluded volume effect and orientational ordering near charged surface in solution of ions and Langevin dipoles. Bioelectrochemistry, 79 (2), pp. 223-227
  Iglic, Ales; Gongadze, Ekaterina; Bohinc, Klemen
  
• 2010. Gap Junction-vermittelte Signaltransmission in kortikalen neuronalen Netzwerken kultiviert auf Neurochips. Biomedizinische Technik/ Biomedical Engineering, 55 (1), p. 33
  Reimer, T., Baumann, W., Koester, P.J. and Gimsa, J.
  
• 2010. Geringer Einfluss der Anisotropie des Gehirns auf das Potential an der Kopfoberfläche. (Small influence of the brain anisotropy on the potential at the scalp). Biomedizinische Technik/ Biomedical Engineering, 55 (1), pp. 216-218
  Rhinow, G., Petersen, S. and van Rienen, U.
  
• 2010. Gold Shark Teeth structures on MEAs - Electroplating of Nano-structures on Metallic Microelectrodes. 7th International Meeting on Substrate-Integrated Microelectrode Arrays, Reutlingen, Germany, pp. 289-290
  Koester, P.J., Tautorat, C., Reimer, T., Zwanzig, M., Baumann, W.H. and Gimsa, J.
  
• 2010. Metal surface in contact with electrolyte solution - Influence of spatial variation of dielectric constant. Elektrotehniski Vestnik, 77(2), pp. 121-130. ISSN: 0013-5852
  Bohinc, K., Gongadze, E., Kralj-Iglič, V., Van Rienen, U. and Iglič, A.
  
• 2010. Osteoblast's sensitivity to topographical and chemical features of titanium. Material Science Forum, 638-642, pp. 652-657
  Nebe, Barbara; Jesswein, Henrike; Weidmann, Arne; Finke, Birgit; Lange, Regina; Beck, Ulrich; Schröder, Karsten
  
• 2010. Physical and electrochemical characterisation of regular microstructred titanium and their influence on cell morphology. Biomedizinische Technik/ Biomedical Engineering, 55 (1), p. 169
  Biala, K., Lange, R., Stählke, S., Nebe, J.B., Und Beck, U.
  
• 2010. Preparation and surface modification of TiMn foams for bone implants. Biomedizinische Technik/Biomedical Engineering, 55 (1), pp. 71-72
  Zhang, F., Otterstein, E., Rott, G.A., Beck, U., Weiss, D.G., and Burkel, E.
  
• 2010. Single-Cell Force Spectroscopy for the determination of initial adhesion of cells to different surfaces. Bone-Tech, Hannover, Germany
  Weihe, T., Bonk, S., Chen, Y., Elter, P. and Gimsa J.
  
• 2010. Soliton collision in biomembranes and nerves-a stability study. 8th Scientific Computing in Electrical Engineering (SCEE), Toulouse, France, 2 pages
  Appali, R., Lautrup, B., Heimburg, T. and van Rienen, U.
  
• 2010. Spatial variation of permittivity near a charged membrane in contact with electrolyte solution, In: Advances in Planar Lipid Bilayers and Liposomes (APLBL), 11, pp. 101-126. ISBN: 978-0-12-381013-7
  Gongadze, E., Bohnic, K., van Rienen, U., Kralj-Iglič, v. and Iglič, A.
  
• 2010. Thermodynamic Theory of Nerve Signal Propagation and First Simulation of Soliton Model. Biomedizinische Technik/ Biomedical Engineering, 55 (1), Rostock, Germany, pp. 186–189
  Appali, R., Petersen, S., Gimsa, J. and van Rienen, U.
  
• 2010. Time dependent analysis of intracellular signaling molecules in osteoblasts on microstructured titanium surfaces. Deutsche Gesellschaft für Biomaterialien (DGBM)., BIOmaterialien, 11, Heiligenstadt, Germany, p. 179. ISSN: 1616-0177
  Staehlke, S., Matschegewski, C., Loeffler, R., Lange, R., Beck, U., Kern, D. and Nebe, J.B.
  
• 2010. Titanium surfaces structured with regular geometry-material investigations and cell morphology. Surface and Interface Analysis, 42(6), pp. 497-501
  Lange, R.; Elter, P.; Biala, K.; Matschegewski, C.; Stählke, S.; Löffler, R.; Fleischer, M.; Nebe, J. B.; Kern, D.; Beck, U.
  
• 2010. WiiLoc: a Step Towards Efficient Device Identification in Large Office Buildings by Wii-Based Localization. IEEE 14th International Conference on Emerging Technologies and Factory Automation (ETFA 2010), pp. 1-6. ISBN: 978-1-4244-6850-8
  Warmuth, R., Goldmann, S. and Salomon, R.
  
• 2010: Vorrichtung und Verfahren zur Insitu-Messung der Verankerungsfestigkeit von Endoprothesen. AZ: DE 102010003279 (A1)
  Bader, R., Ewald, H., Klüss, D., Mittelmeier, W., Souffrant, R., Woernle, C.
  
• Zellreaktor. AZ: DE102010064098.0
  Bergemann, C., Hansmann, H., Kunz, F., Nebe, B., Weissmaqnn, V., Wetzel, J.
  
• 2011 The influence of topographic microstructures on the initial adhesion of L929 fibroblasts studied by single-cell force spectroscopy. European Journal of Biophysics, 40, pp. 317-324
  Elter, Patrick; Weihe, Thomas; Lange, Regina; Gimsa, Jan; Beck, Ulrich
  
• 2011. A unifying approach to isotropic and anisotropic total variation denoising models. Journal of Applied Computer Science and Mathematics, 235(8), pp. 2502-2514
  Birkholz, Harald
  
• 2011. Adhesion of osteoblasts to a nanorough titanium implant surface. International Journal of Nanomedicine, 6, pp. 1801–1816
  Gongadze, Ekaterina; Kabaso, Doron; Bauer, Sebastian; Slivnik, Tomaž; Schmuki, Patrik; van Rienen, Ursula; Iglič, Aleš
  
• 2011. Agent-based simulation of molecular processes. An application to actin-polymerisation. Conference SIMULTECH - Proceedings of 1st International Conference on Simulation and Modeling Methodologies, Technologies and Applications, Noordwijkerhout, The Netherlands, pp. 276-282
  Pauleweit, S., Nebe J. B. and Wolkenhauer, O.
  
• 2011. Ammonia Plasma Functionalized Polycarbonate Surfaces Improve Cell Migration Inside an Artificial 3D Cell Culture Module. Plasma Processes and Polymers, pp. 261-272
  Bergemann, Claudia; Quade, Antje; Kunz, Friederike; Ofe, Stefan; Klinkenberg, Ernst-Dieter; Laue, Michael; Schröder, Karsten; Weissmann, Volker; Hansmann, Harald; Weltmann, Klaus-Dieter; Nebe, Barbara
  
• 2011. Analyse der Interaktion von Osteoblasten auf mikrostrukturierten Oberflächen in Bezug auf die Organisation des Aktinzytoskeletts. Deutsche Gesellschaft für Biomaterialien (DGBM), BIOmaterialien 12, 1-4, Gießen, Germany, p.115. ISSN: 1616-0177
  Staehlke, S., Matschegewski, C., Loeffler, R., Lange, R., Beck, U., Kern, D. and Nebe. J.B.
  
• 2011. Attachment of rod-like (BAR) proteins and membrane shape. Mini-Reviews in Medicinal Chemistry, 11(4), pp. 272-282
  Kabaso, D.; Gongadze, E.; Elter, P.; van Rienen, U.; Gimsa, J.; Kralj-Iglič, V.; Iglič, A.
  
• 2011. Combination of neural-mass models with anisotropic head models to simulate EEG signals. 8th International Conference on Computation in Electromagnetics (CEM), pp. 108-109. ISBN: 978-1-84919-468-6
  Zimmermann, U., Petersen, S., Schwabe, L. and van Rienen, U.
  
• 2011. Der Effekt endogener Amine in elektrogesponnenen Polylactid-Scaffolds auf die Zelladhäsion. 7. Thüringer Grenz- und Oberflächentage und 8. Thüringer Biomaterial-Kolloquium, Tagungsband, pp. 319-323. ISBN: 978-3-00-035347-5
  Wyrwa, R., Mueller, U., Bergemann, C., Kunz, F., Nebe, J.B. and Schnabelrauch, M.
  
• 2011. Derivation of Langevin Poisson-Boltzmann equation for point-like ions using functional density theory. Elektrotehniski Vestni, 78(1), pp. 13-6
  Gongadze, E., Kralj-Iglič, V., van Rienen, U. and Iglič, A.
  
• 2011. Dielectric Properties of Porous Calcium Titanate (CaTiO3). The American Ceramic Society's Ceramic Transactions proceedings. Biomaterials Science - Processing, Properties, and Applications: Ceramic Transactions, 228, pp. 89-95
  Rott, G.A., Zhang, F., Haba, Y., Kroeger, W. and Burkel, E.
  
• 2011. Electromechanical basis for the interaction between osteoblasts and negatively charged titanium surface, In: Advances in Planar Lipid Bilayers and Liposomes (APLBL), 13(6), pp. 197-219. ISSN: 1554-4516
  Gongadze, E., Perutková, Š., Kralj-Iglič, V., van Rienen, U., Beck, U., Iglič, A., & Kabaso, D.
  
• 2011. Electrostatics and mechanics of the interactions between osteoblasts and a surface of titanium implants, 21st International Symposium on Bioelectrochemistry and Bioenergetics, Cracow, Poland, p. 297
  Iglič, A., Gongadze, E., Kabaso, D., Perutkova, Š., Kralj-Iglič, V., Iglič, A. and van Rienen, U.
  
• 2011. Exploring the binding dynamics of BAR proteins. Cellular and Molecular Biology Letters, 16 (3), pp. 398-411
  Kabaso, Doron; Gongadze, Ekaterina; Jorgačevski, Jernej; Kreft, Marko; van Rienen, Ursula; Zorec, Robert; Iglič, Aleš
  
• 2011. Extracting the Ridge Set as a Graph for Quantification of Actin Filament Images obtained by Confocal Laser Scanning Microscopy. Tenth International Conference on Quality Control by Artificial Vision, Proceedings of SPIE, 8000
  Birkholz, H
  
• 2011. Generalized Stern models of the electric double layer considering the spatial variation of permittivity and finite size of ions in saturation regime. Cellular and Molecular Biology Letters, pp. 576-594
  Gongadze, Ekaterina; van Rienen, Ursula; Iglič, Aleš
  
• 2011. Impact of plasma polymer deposition on titanium on osteoblasts with disturbed cell functions due to impaired actin cytoskeleton. BIOmaterialien, 12(1-4), p. 199
  Kunz, F., Quade, A., Schroeder, K., Matschegewski, C. and Nebe, J.B.
  
• 2011. Improvement in Cytoarchitectonic Mapping by Combining Electrodynamic Modeling with Local Orientation in High- Resolution Images of the Cerebral Cortex. Microscopic Research and Technique, 74, pp. 225–243
  Schmitt, Oliver; Birkholz, Harald
  
• 2011. Influence of the Electric Double Layer on the Field Distribution in Deep Brain Stimulation. Biomedizinische Technik/Biomedical Engineering, 56 (1), p. 103
  Schmidt, C., Petersen, S. and van Rienen, U.
  
• 2011. Langevin Poisson-Boltzmann equation: point-like ions and water dipoles near a charged membrane surface. General Physiology and Biophysics, 30 (2), pp.130-137
  Gongadze, Ekaterina; van Rienen, Ursula; Kralj-Iglič, Veronika; Iglič, Aleš
  
• 2011. Mechanics and electrostatics of the interactions between cells and surface of titanium implants, 18th Meeting European Association of Red Cell Research (EARCR), Wroclaw-Piechowice, Poland, p. 25
  Iglič, A., Gongadze, E., Kabaso, D., Perutkova, Š., van Rienen, U. and Kralj-Iglič, V.
  
• 2011. Mechanics and electrostatics of the interactions between osteoblasts and titanium surface. Computer Methods in Biomechanics and Biomedical Engineering, 14(5), pp. 469-482
  Kabaso, D., Gongadze, E., Perutková, Š., Matschegewski, C., Kralj-Iglič, V., Beck, U., van Rienen, U. and Iglič, A.
  
• 2011. Optimizing a rodent model of Parkinson's disease for exploring the effects and mechanisms of deep brain stimulation. Parkinson's Disease, 2011, pp. 1-19
  Nowak, Karl; Mix, Eilhard; Gimsa, Jan; Strauss, Ulf; Sriperumbudur, Kiran Kumar; Benecke, Reiner; Gimsa, Ulrike
  
• 2011. Quantification of intracellular structures as a tool for the correlation of material vs. cellular parameters. Biomedizinische Technik/Biomedical Engineering, 56 (s1):4, Freiburg, Germany, pp.141-167
  Matschegewski, C., Birkholz, H., Staehlke, S., Loeffler, R., Kern, D.P., Engel, K. and Nebe, J.B.
  
• 2011. Randomized Goodness of Fit Tests. Kybernetika, 47(6), pp. 814-839
  Liese, F., & Liu, B.
  
• 2011. SRD - Towards a System for the In-Situ Detection of the Stapedius Reflex. IEEE Symposium Series on Computational Intelligence (SSCI 2011), pp. 29 - 34
  Lueder, M., Warmuth, R., Heinrich, E., Joost, R. and Salomon, R.
  
• 2011. Structured titanium surfaces with regular geometry prepared with different technologies and their influence on MG-63 cell morphology. Microscopy Conference, Kiel, Germany
  Lange, R., Löffler, R., Staehlke, S., Elter, P., Nebe, J.B., Kern, D. and Beck, U.
  
• 2011. The stability of solitons in biomembranes and nerves. European Physical Journal, 34 (6), pp. 1-9
  Lautrup, B.; Appali, R.; Jackson, A. D.; Heimburg, T.
  
• 2011. Vergleich der Vitalität und Kollagensynthese humaner, primärer Osteoblasten unter dem Einfluss der elektrischen Stimulation in-vitro. Osteologie, 20 (1), pp. 61-62. ISSN: 1019-1291
  Marrot, A., Jonitz, A., Grunert, P., Haba, Y., Hansmann, D. and Bader, R.
  
• Mathematical Methods for the Quantification of Actin-Filaments in Microscopic Images. Mathematisch-Naturwissenschaftliche Fakultät
  Harald Birkholz
  
• 2012. A comparison of the Hodgkin-Huxley model and the soliton theory for the action potential in nerves, In: Advances in Planar Lipid Bilayers and Liposomes (APLBL), Elsevier, Vol.16 (2012), pp: 275-299. ISSN: 1554-4516
  Appali, R., Van Rienen, U., & Heimburg, T.
  
• 2012. About Electromyographic Signals and the Automatic Detection of the Stapedius Reflex. Inner Ear Biology, 3 pages
  Warmuth, R., Behrens, M., Dahl, R., Pau, H-W. and Salomon, R.
  
• 2012. Actin cytoskeleton mediated cell response of osteoblasts to plasma amino functionalised titanium surfaces. 4th International Symposium Interface Biology of Implants (IBI), Rostock, Germany, Abstracts, p.49
  Kunz, F., Quade, A., Matschegewski, C., Staehlke, S., Birkholz, H., Rebl, H., Steffen, J. and Nebe, J.B.
  
• 2012. Automatic Actin Filament Quantification of Osteoblasts and their Morphometric Analysis on Microtextured Silicon-titanium Arrays. Materials, 5, pp. 1176-1195
  Matschegewski, C., Staehlke, S., Birkholz, H., Lange, R., Beck, U., Engel, K., & Nebe, J. B.
  
• 2012. Bone mineral densities and mechanical properties of retrieved femoral bone samples in relation to bone mineral densities measured in the respective patients. Scientific World Journal, Article ID 242403, pp. 1-7
  Haba, Yvonne; Skripitz, Ralf; Lindner, Tobias; Köckerling, Martin; Fritsche, Andreas; Mittelmeier, Wolfram; Bader, Rainer
  
• 2012. Characterization of the encapsulation process of deep brain stimulation electrodes using impedance spectroscopy in a rodent model. Proceedings of the International Conference on Bio-inspired Systems and Signal Processing, 1, Biosignals, Biostec, Vilamoura Algarve, Portugal, pp.125-130. ISBN: 978-989-8425-89-8
  Badstuebner, K., Kroeger, T., Mix, E., Gimsa, U., Benecke, R. and Gimsa, J.
  
• 2012. Correlation of calcium channel expression and actin organization – bone cells on microstructures. Deutsche Gesellschaft für Biomaterialien (DGBM), BioNanoMaterials, 13 (1-4), Hamburg, Germany, p. 219. ISSN 2193-0651
  Steffen, J., Staehlke, S., Matschegewski, C., Kunz, F., Loeffler, R. and Nebe, J.B.
  
• 2012. Design strategies for weight matrices of echo state networks. Neural Computation, 24, pp. 3246-3276
  Strauss, Tobias; Wustlich, Welf; Labahn, Roger
  
• 2012. Electrochemical and scanning electron microscopic characterization of biomaterial surfaces with regular geometry dry etched in Titanium. 4th International Symposium Interface Biology of Implants, p. 51. ISBN: 978-3-00-038220-8
  Lange, R., Loeffler, R., Staehlke, S., Elter, P., Koertge, A., Nebe, J.B., Ker, D. and Beck, U.
  
• 2012. Extracting the ridge set as a graph for actin filament length estimation from confocal laser scanning microscopic images. Journal of Electronic Imaging, 21 (2), pp. 1-9
  Birkholz, Harald
  
• 2012. Identification of widely applicable configurations for the electrostimulative total hip revision system. 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 3048-3051
  Zimmermann, U. and van Rienen, U.
  
• 2012. Low fibronectin concentration overcompensates for reduced initial fibroblasts adhesion to a nanoscale topography: Single-cell force spectroscopy. Colloids and Surfaces B: Biointerfaces, 95, pp. 82-89
  Elter, Patrick; Weihe, Thomas; Bühler, Sebastian; Gimsa, Jan; Beck, Ulrich
  
• 2012. Modelling the Field Distribution in Deep Brain Stimulation: The Influence of Anisotropy of Brain Tissue. IEEE Transactions on Biomedical Engineering, 59, pp. 1583-1592
  Schmidt, Christian; van Rienen, Ursula
  
• 2012. Osteoblast Behavior in vitro in Porous Calcium Phosphate Composite Scaffolds, Surface Activated with a Cell Adhesive Plasma Polymer Layer. Materials Science Forum. Trans Tech Publications, pp. 566-571
  Nebe, Barbara; Cornelsen, Matthias; Quade, Antje; Weissmann, Volker; Kunz, Friederike; Ofe, Stefan; Schroeder, Karsten; Finke, Birgit; Seitz, Hermann; Bergemann, Claudia
  
• 2012. Population bursts of parvalbumin-positive interneurons inhibit spiking pyramidal cells in spontaneously active cortical in vitro networks. Journal of Chemistry and Chemical Engineering, 6, pp. 1033-1042
  Tom Reimer, Werner Baumann and Jan Gimsa
  
• 2012. PoreGenic® ‐ Patch‐on‐Chip System for Adherent Cellular Networks. Biophysical Society Meeting, 102 (3), p. 583a
  Franz, D., Tautorat, C., Scheffler, U., Klink, O., Kroeger, T., Gimsa, J., W. Baumann, W., Beikirch, H. and Koester, P.J.
  
• 2012. Pyramid Array Substrates for Biomedical Studies. Deutsche Gesellschaft für Biomaterialien (DGBM), BioNanoMaterials, 13 (1-4), Hamburg, Germany, p.74. ISSN: 2193-0651
  Loeffler, R., Matschegewski, C., Staehlke, S., Nebe, J.B., Fleischer, M. and Kern, D.P.
  
• 2012. Pyramid Array Substrates for Biomedical Studies. Journal of Vacuum Science and Technology B, 6(30), pp. 1-12
  Loeffler, R., Fleischer, M., Matschegewski, C., Staehlke, S., Lange, R., Nebe, J.B. and Kern, D.P.
  
• 2012. Quantification of uncertainties in brain tissue conductivity in a heterogeneous model of deep brain stimulation using a non-intrusive projection approach. 34th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), San Diego, USA, pp. 4136-4139
  Schmidt, C. and van Rienen, U.
  
• 2012. Quantitative analysis of the cellular actin cytoskeleton on geometrically designed surface topography. Mater Science Forum 706-709, pp.543-548. ISBN-13: 978-3-03785-303-0
  Matschegewski, C., Birkholz, H., Staehlke, S., Loeffler, R., Kern, D.P., Engel, K. and Nebe, J.B.
  
• 2012. Quantitative analysis of the cellular actin cytoskeleton on geometrically designed surface topography. Materials Science Forum, 706-709, pp. 543-548
  Matschegewski, Claudia; Birkholz, Harald; Staehlke, Susanne; Loeffler, Ronny; Kern, Dieter P.; Engel, Konrad; Nebe, Barbara
  
• 2012. Relationship between mechanical properties and bone mineral density of human femoral bone retrieved from patients with osteoarthritis. The Open Orthopaedics Journal, 6, pp. 375-380
  Haba, Yvonne; Lindner, Tobias; Fritsche, Andreas; Schiebenhöfer, Ann-Kristin; Souffrant, Robert; Kluess, Daniel; Skripitz, Ralf; Mittelmeier, Wolfram; Bader, Rainer
  
• 2012. Sensitivity analysis of the field distribution in Deep Brain Stimulation with respect to the anisotropic conductivity of brain tissue. 46. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik im VDE (BMT). Biomedizinische Technik/Biomedical Engineering, 57
  Schmidt, C. and van Rienen, U.
  
• 2012. Soliton Collision in Biomembranes and Nerves- A Stability Study, in B. Michielsen, J. Poirier (Eds.) Scientific Computing in Electrical Engineering Springer, Mathematics in Industry, Vol. 16, pp: 205–212
  Appali, Revathi; Lautrup, Benny; Heimburg, Thomas; van Rienen, Ursula
  
• 2012. Spontaneous activity patterns of cortical in vitro networks depend on cellular network composition. Proceedings of the 8th Internationale Meeting in Substrate-Integrated Microelectrode Arrays, Reutlingen, Germany, pp. 98-99
  Reimer, T., Baumann, W. and Gimsa, J.
  
• 2012. Vorrichtung zur elektrischen Impedanz-Analyse an schwer zugänglichen Orten. AZ: DE 102012200529.3
  Haba, Y., Bader, R., Souffrant, R., Kluess, D., Kreuz, P.
  
• Influence of the Surface Structure of a Biomaterial on the Field Distribution in the Neighbouring Biosystem. Mathematisch-Naturwissenschaftliche Fakultät
  Ekaterina Gongadze
  
• Statistische Analyse von Aktinfilamenten und Anpassungstests mit geschätzten Parametern. Mathematisch-Naturwissenschaftliche Fakultät
  Bing Liu
  
• 2013. Alignment of MG-63 osteoblasts on fibronectin-coated phosphorous doping lattices in silicon. International Journal of Chemical and Molecular Engineering, 7 (1), pp. 62-65
  Andreas Körtge, Susanne Stählke, Regina Lange, Mario Birkholz, Mirko Fraschke, Katrin Schulz, Barbara Nebe, and Patrick Elter
  
• 2013. Alignment of MG-63 osteoblasts on fibronectin-coated phosphorous doping lattices in silicon. World Academy of Science, Engineering and Technology, International Journal of Chemical and Molecular Engineering, 7 (1), pp. 70-73
  Koertge, A., Staehlke, S., Lange, R., Birkholz, M., Fraschke, M., Schulz, K., Nebe, B.J. and Elter, P.
  
• 2013. Changes of the electric field distribution in the femoral head due to position and design of an electro-stimulating implant. Biomed Tech, 2 pages. ISSN: 1862-278X
  Su, Y., Souffrant, R., Kluess, D., Ellenrieder, M., van Rienen, U., Mittelmeier, W. and Bader, R.
  
• 2013. Dependence of the electric field distribution in the femoral head on position and design of an electro-stimulating implant. Biomedical Engineering / Biomedizinische Technik, Band 58, Dreiländertagung der Deutschen, Schweizerischen und Österreichischen Gesellschaft für Biomedizinische Technik, Graz, Austria, 2 pages
  Su, Y., Souffrant, R., Kluess, D., Ellenrieder, M., van Rienen, U., Mttelmeier, W. and Bader, R.
  
• 2013. Effects of Brownian motion on electrical double layer. Biomedical Engineering / Bio-medizinische Technik, Band 58, Dreiländertagung der Deutschen, Schweizerischen und Österreichischen Gesellschaft für Biomedizinische Technik, Graz, Austria, 3 pages
  Syed, A. Z., Van Rienen, U. and Elter, P.
  
• 2013. Electrical impedance properties of deep brain stimulation electrodes during long-term in-vivo stimulation in the Parkinson model of the rat. Biomedical Engineering Systems and Technologies, BIOSTEC, Communications in Computer and Information Science, 357, Springer, Berlin, Heidelberg, 357, pp. 287-297. ISBN: 978-3-642-38256-7
  Badstuebner, K., Kroeger, T., Mix, E., Gimsa, U., Benecke, R. and Gimsa, J.
  
• 2013. Etablierung eines dreidimensionalen Versuchsaufbau zur elektromagnetischen Stimulation humaner Osteoblasten in vitro. Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU), Berlin, Germany
  Jonitz, A., Grunert, P., Su, Y., Fabry, C., Hansmann, D., Ewald, H., Mittelmeier; W., and Bader, R.
  
• 2013. Global Sensitivity Analysis of the Probabilistic Volume of Tissue Activated in a Volume Conductor Model for Deep Brain Stimulation. 6th International IEEE EMBS Conference on Neural Engineering (NER), San Diego, USA, IEEE Conference Publications, pp. 1218 – 1221. ISSN: 1948-3554
  Schmidt, C. and van Rienen, U.
  
• 2013. In-vitro-Bestimmung der Membraneigenschaften für ein möglichst realistisches Cochlea-Modell. 16. Jahrestagung der deutsche Gesellschaft für Audiologie (DGA), Rostock, Germany. ISBN 978-3-9813141-3-7
  Holst, M., Pau, H-W., Behrend, D., Koehling, R., und van Rienen, U.
  
• 2013. Influence of Uncertainties in the Material Properties of Brain Tissue on the Probabilistic Volume of Tissue Activated. IEEE Transactions on Biomedical Engineering, 60 (5), pp. 1378-1387
  Schmidt, Christian; Grant, Peadar; Lowery, Madeleine; van Rienen, Ursula
  
• 2013. Modelling and simulation of an in-vitro experimental set-up to determine membrane electric properties. Biomedical Engineering / Biomedizinische Technik, Band 58, Dreiländertagung der Deutschen, Schweizerischen und Österreichischen Gesellschaft für Biomedizinische Technik, Graz, Austria, pp. 747-748. ISSN 1862-278X
  Holst, M., Pau, H-W. and van Rienen, U.
  
• 2013. Modelling Molecular Processes by Individual-Based Simulations Applied to Actin Polymerisation. An application to Actin-polymerisation. Simulation and Modeling Methodologies, Technologies and Applications Advances in Intelligent Systems and Computing, 197, pp. 183-191
  Pauleweit, Stefan; Nebe, J. Barbara; Wolkenhauer, Olaf
  
• 2013. Modelling the Probabilistic Neural Activation in Deep Brain Stimulation: Influence of Uncertainty in the Parameters of the Electrode-Tissue-Interface. URSI International Symposium on Electromagnetic Theory (EMTS), Hiroshima, Japan, IEEE, pp. 365-368. ISBN: 978-4-88552-277-2
  Schmidt, C. and van Rienen, U.
  
• 2013. PoreGenic® - Patch-on-Chip System für die präklinische Forschung an Ionenkanälen. 11. Dresdner Sensor‐Symposium, Verlag der Wissenschaften GmbH, Dresden, Germany, pp. 68-72. ISBN 978-3-9813484-5-3
  Franz, D., Tautorat, C., Scheffler, U., Klink, O., Kröger, T., Gimsa, J., W. Baumann, W., Beikirch, H. and Koester, P.J.
  
• 2013. Rapid-Prototyping von Dünnschichtsensoren für Zellkulturchips durch direkte Strukturierung mit einem Ultra-Kurzpulslaser, Conference: Mikrosystemtechnik 2013 - Von Bauelementen zu Systemen, Aachen, Germany, pp. 830-833
  Bonk, S.M., Oldendorf, P., Weihe, T., Stubbe, M., Peters, R. and Gimsa, J.
  
• 2013. Regulation of T-type calcium channels in osteoblasts on micro-structured surface topography. Advanced Materials Research, 647, pp. 476-481
  Staehlke, Susanne; Kunz, Friederike; Loeffler, Ronny; Matschegewski, Claudia; Fleischer, Monika; Kern, Dieter P.; Nebe, Barbara
  
• 2013. Simulation of the Electric Field Distribution near a Topographically Nanostructured Titanium- Electrolyte Interface: Influence of the Passivation Layer. Journal of Nanomaterials. Article ID 820914
  Körtge, Andreas; Elter, Patrick; Lange, Regina; Beck, Ulrich
  
• 2013. Single Frequency Approximation of Volume Conductor Models for Deep Brain Stimulation Using Equivalent Circuits. 6th International Joint Conference on Biomedical Engineering Systems and Technologies. Barcelona, Spain, pp. 38-47
  Schmidt, C. and van Rienen, U.
  
• 2013. Some Uncertainty Aspects in Models for Neural Engineering. International Conference on Electromagnetics in Advanced Applications (ICEAA), Torino, Italy, IEEE, pp. 289-292
  Appali, R., Schmidt, C. and van Rienen, U.
  
• 2013. Spatial variation of permittivity of an electrolyte solution in contact with a charged metal surface: a mini review. Computer Methods in Biomechanics and Biomedical Engineering, 16 (5), pp. 463-480
  Gongadze, E.; van Rienen, U.; Kralj-Iglič, V.; Iglič, A.
  
• Kortikale neuronale Netzwerke auf Multielektrodenarrays als reduktionistischer Ansatz zur Aufklärung der Funktionsprinzipien des zerebralen Kortex. Mathematisch-Naturwissenschaftliche Fakultät
  Tom Reimer
  
• 2014. An automatic modeling approach for optimised positioning of an electrostimulative implant in the human femoral head. In COMSOL Conference, Cambridge, 3 pages
  Su, Y., Kluess, D., Ellenrieder, M., van Rienen, U., Mittelmeier, W. and Bader, R.
  
• 2014. An automatic optimized position of an electrostimulative implant in the femoral head for treatment of avascular necrosis. Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014), DocPO21-744
  Su, Y., Kluess, D., Ellenrieder, M., van Rienen, U., Mittelmeier, W. and Bader, R.
  
• 2014. Automatic detection of the electrical elicited stapedius reflex by evaluation of its electromyographic signals. Engineering. 6, (4), pp. 169-176
  Warmuth, Ralf; Behrens, Martin; Dahl, Rüdiger; Ehrt, Karsten; Pau, Hans Wilhelm; Salomon, Ralf
  
• 2014. Biphasic response of neuronal networks to sodium valproic acid (NaVPA). 9th international Meeting on Substrate-integrated Microelectrode Arrays, Reutlingen, Germany, p. 126. ISSN: 2199-1596
  Nissen, M., Buehler, S., Stubbe, M., Baumann, W. and Gimsa, J.
  
• 2014. Comparison of techniques for uncertainty quantification of superconducting radio frequency cavities. Proceedings of the International Conference on Electromagnetics in Advanced Applications (ICEAA), Palm Beach, Aruba, pp. 117-120
  Schmidt, C., Flisgen, T., Heller, J. and Van Rienen, U.
  
• 2014. Einrichtung zum Flüssigkeitstransport durch einen Mikrofluidikkanal. AZ: DE102014207238 (A1)
  Bonk, S.
  
• 2014. Einrichtung zur Flusssteuerung durch einen Mikrofluidikkanal. AZ: DE102014207249 (A1)
  Bonk, S.
  
• 2014. Establishment of a novel in vitro test setup for electric and magnetic stimulation of human osteoblasts. Cell Biochemistry and Biophysics, 70(2), pp. 805-17
  Grunert, P. C.; Jonitz-Heincke, A.; Su, Y.; Souffrant, R.; Hansmann, D.; Ewald, H.; Krüger, A.; Mittelmeier, W.; Bader, R.
  
• 2014. Evaluation of electric field distribution in electromagnetic stimulation of human femoral heads. Bioelectromagnetics, 35(8), pp. 547-558
  Su, Yukun; Souffrant, Robert; Kluess, Daniel; Ellenrieder, Martin; Mittelmeier, Wolfram; van Rienen, Ursula; Bader, Rainer
  
• 2014. Geometrical micropillars combined with chemical surface modifications – Independency of actin filament Spatial distribution in primary osteoblasts. Material Science Forum, 783-786, pp.1320-1325
  Nebe, J. Barbara; Finke, Birgit; Koertge, Andreas; Rebl, Henrike; Staehlke, Susanne
  
• 2014. Impact of the chemistry of geometrically designed titanium on cell behavior and alignment. BioNanoMat. 15, S1, p. 22. ISSN 2193-0651
  Moerke, C., Finke, B., Schnabelrauch, M., Anselme, K. and Nebe, J.B.
  
• 2014. Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model. BMC Systems Biology, 8(106), pp.1-19
  Bittig, Arne T.; Matschegewski, Claudia; Nebe, J. Barbara; Stählke, Susanne; Uhrmacher, Adelinde M.
  
• 2014. Mikrofluidik, innere Sensorik und Strukturentwurf für ein 3D-Zellkultursystem. In H.-G. Neumann, E.-D. Klinkenberg (Eds.): Knöcherne Geweberegeneration. Zellphysiologie im Dreidimensionalen, 73–112. 1. Aufl., Shaker-Verlag GmbH, Herzogenrath.. ISBN 978-3-8440-3049-5
  Walter, S., Bonk, S., Stubbe, M., Baumann, W. and Gimsa, J.
  
• 2014. Numerical investigation of an electrostimulative hip stem with a multi-electrode setting. 10th International Conference on Scientific Computing in Electrical Engineering (SCEE), Wuppertal, Germany, pp. 79-80
  Zimmermann,U., Ebner, C., Bader, R. and van Rienen, U.
  
• 2014. On the Influence of Cancellous Bone Structure upon the Electric Field Distribution of Electrostimulative Implants. In COMSOL Conference, Cambridge, UK, 3 pages
  Zimmermann, U., Bader, R. and van Rienen, U.
  
• 2014. On the optimization of the hip stem for an electrostimulative hip revision system. URSI General Assembly and Scientific Symposium (URSI GASS), Beijing, China, IEEE, pp. 1-4
  Zimmermann, U. and van Rienen, U.
  
• 2014. Partition into almost straight trails. Discrete Applied Mathematics, 163, pp.127–135
  Birkholz, Harald; Engel, Konrad
  
• 2014. Quantification of geometric uncertainties in single cell cavities for BESSY VSR using polynomial chaos. 5th International Particle Accelerator Conference (IPAC), pp. 415-417. ISBN 978-3-95450-132-8
  Heller, J., Flisgen, T., Schmidt, C. and van Rienen, U.
  
• 2014. Reconstruction of cell-electrode-adjacencies on multielectrode arrays. Journal of Computational Neuroscience, 37 (3), pp. 583-591
  Engel, Konrad; Hanisch, Sebastian
  
• 2014. The CombineArchiveWeb application–A web based tool to handle files associated with modelling results. Proceedings of the Semantic Web Applications and Tools for Life Sciences (SWAT4LS)
  Scharm, M., Wendland, F., Peter, M., Wolfien, M., Theile, T. and Waltemath, D.
  
• 2014. The Stapedius Reflex: Processing its neuronal activity with a small embedded system. International Joint Conference on Neural Networks (IJCNN), Beijing, China, IEEE, pp. 3938 - 3943
  Warmuth, R. and Salomon, R.
  
• 2014. Uncertainty quantification of the optimal stimulation area in an electro-stimulative hip revision system. Engineering in Medicine and Biology Society (EMBC). 36th Annual International Conference of the IEEE, pp. 824-827
  Schmidt, C., Zimmermann, U. and van Rienen, U.
  
• 2014. Verfahren und Vorrichtung zur Einstellung mindestens eines Verstärkungsfaktors. AZ: DE 10 2013 214 049.5
  Salomon, R. und Warmuth, R.
  
• 2014. Would an endosteal CI-electrode make sense? Comparison of the auditory nerve excitability from different stimulation sites using ESRT measurements and mathematical models. European Archives of Otorhinolaryngology, 271(6), pp. 1375-1381
  Pau, Hans Wilhelm; Grünbaum, Annekathrin; Ehrt, Karsten; Dahl, Rüdiger; Just, Tino; van Rienen, Ursula
  
• 2014. Zellmigration in vitro in einem artifiziellen 3D Layer-Modell. In: Knöcherne Geweberegeneration: Zellphysiologie im Dreidimensionalen, pp 131-142. Hans-Georg Neumann, Ernst-Dieter Klinkenberg (Herausgeber), Shaker Verlag GmbH, Aachen, ISBN 987-3- 8440-3049-5
  Bergemann, C., Kunz, F., Quade, A. and Nebe, J.B.
  
• Analyse initialer Adhäsionsmechanismen von humanen Osteoblasten in Abhängigkeit physiko-chemischer Oberflächencharakteristika definiert mikrostrukturierter Titanoberflächen. Mathematisch-Naturwissenschaftliche Fakultät
  Claudia Matschegewski
  
• Entwicklung eines detaillierten Modells der humanen Cochlea für numerische Studien von implantierten Elektroden. Fakultät für Informatik und Elektrotechnik
  Annekathrin Grünbaum
  
• Interaktionen von humanen Osteoblasten mit geometrisch strukturierten Implantatoberflächen : Zellarchitektur und Signaltransduktion. Universitätsmedizin Rostock
  Susanne Stählke
  
• Modelling the coupling of action potential and electrodes. Fakultät für Informatik und Elektrotechnik
  Revathi Appali
  
• Uncertainty quantification in a computationally optimised volume conductor model for deep brain stimulation. Fakultät für Informatik und Elektrotechnik
  Christian Schmidt
  
• 2015. "Mehrebenensysteme in der Biomedizin." Buchkapitel in Thalheim, Bernhard, and Ivor Nissen, eds. Wissenschaft und Kunst der Modellierung: Kieler Zugang zur Definition, Nutzung und Zukunft. Vol. 64. Walter de Gruyter GmbH & Co KG. ISBN: 9781501510403
  Tom Theile und Olaf Wolkenhauer
  
• 2015. 3D axonal network coupled to microelectrode arrays: A simulation model to study neuronal dynamics. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milano, Italy, pp. 4700 - 4704
  Appali, R., Sriperumbudur, K. and van Rienen, U.
  
• 2015. Attempted caveolae-meadiated phagocytosis of surface-fixed micro-pillars by human osteoblasts. Biomaterials, 76, pp. 102-114
  Moerke, Caroline; Mueller, Petra; Nebe, Barbara
  
• 2015. Behaviour of the plathelminth symsagittifera roscoffensis under different light conditions and the consequences on the symbiotic algae tetraselmis convolutae. The Journal of Experimental Biology, 218(pt 11), pp. 1693-1698
  Nissen, Matthias; Shcherbakov, Denis; Heyer, Arnd; Brümmer, Franz; Schill, Ralph O.
  
• 2015. Design and characterization of pH, oxygen and adhesion sensors as well as electro-thermal micro-pumps (ETµPs) for glass chips in sensorized cell-culture systems. Biosensors, 5, pp. 513- 536
  Bonk, Sebastian M.; Stubbe, Marco; Buehler, Sebastian M.; Tautorat, Carsten; Baumann, Werner; Klinkenberg, Ernst-Dieter; Gimsa, Jan
  
• 2015. Electrical stimulation of spiral ganglion cells in the human cochlea: A 3D model. 20th Int. Conference on the Computation of Electromagnetic Fields (COMPUMAG 2015), Montreal, Canada, doc. PC1-11, 2 pages
  Sriperumbudur, K., Pau, H.N. and van Rienen, U.
  
• 2015. Fast prototyping of sensorized cell culture chips and microfluidic systems with ultrashort laser pulses. Micromachines, 6, pp. 364-374
  Bonk, Sebastian; Oldorf, Paul; Peters, Rigo; Baumann, Werner; Gimsa, Jan
  
• 2015. Formkörper enthaltend piezoelektrisches Calciumtitanoxid, ein Verfahren zu deren Herstellung und Anregung und Verwendung piezoaktiven Calciumtitanoxids als piezoelektrischer Formkörper oder Bestandteil piezoelektrischer Formkörper. AZ: DE102015108865.7
  Burkel, E. and Schnierer, R.
  
• 2015. Impact of uncertain head tissue conductivity in the optimization of transcranial direct current stimulation for an auditory target. Journal of Neural Engineering, 12 (4), Epub 046028
  Schmidt, Christian; Wagner, Sven; Burger, Martin; van Rienen, Ursula; Wolters, Carsten H.
  
• 2015. In-vitro analysis of the antimicrobial properties of magnesium-coated titanium implants. Track A. Biomaterials and Biocompatibility 1. Biomed Tech, 60, Berlin, Germany S1
  Zaatreh, S., Haffner, D., Pasold, J., Kreikemeyer ,B., Mittelmeier, W., Podbielski, A., Quandt, E. and Bader, R.
  
• 2015. Intracellular calcium dynamics dependent on defined micro-topographical features of titanium. Biomaterials, 46, pp. 48-57
  Staehlke, Susanne; Koertge, Andreas; Nebe, Barbara
  
• 2015. Investigation of the Electric Field Distribution within an Electrostimulated Microstructure of Cancellous Bone. 20th Int. Conference on the Computation of Electromagnetic Fields (COMPUMAG 2015), Montréal, Canada, doc. PC1-7, 2 pages
  Zimmermann, U. and van Rienen , U.
  
• 2015. Modeling and simulation of platelet reaction and diffusion towards an electro-stimulating dental implant. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milano, Italy. pp. 2584 - 2587
  Delenda, B., Bader, R. and van Rienen, U.
  
• 2015. Modeling of an optimized electro-stimulative hip revision system under consideration of uncertainty in the conductivity of bone tissue. IEEE Journal of Biomedical and Health Informatics, 19 (4), pp. 1321-1330
  Schmidt, Christian; Zimmermann, Ulf; van Rienen, Ursula
  
• 2015. Osteoblasts with impaired spreading capacity benefit from the positive charges of plasma polymerized allylamine. European Cells and Materials 29, pp. 177-189
  Kunz, F., Rebl, H., Quade, A., Matschegewski, C., Finke, B. and Nebe, J.B.
  
• 2015. Osteoblasts with impaired spreading capacity benefit from the positive charges of plasma polymerized allylamine. European Cells and Materials, 29, pp. 177-189
  Kunz, F.; Rebl, H.; Quade, A.; Matschegewski, C.; Finke, B.; Nebe, J. B.
  
• 2015. PoreGenic® - Patch-on-Chip System für die präklinische Forschung an Ionenkanälen – Teil II. 12. Dresdner Sensor‐Symposium, Dresden, Germany, pp. 118-123. ISBN 978-3-9813484-9-1
  Tautorat, C., Scheffler, U., Franz, D., Kroeger, T., Koester, P.J., Baumann, W., Klink, O. and Beikirch, H.
  
• 2015. Signal initiation sites on spiral ganglion cells: A simulation study. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milano, Italy, 1 page. ISBN: 978-1-4244-9270-1
  Sriperumbudur, K., Pau, H.W., Mylinski, R. and van Rienen
  
• 2015. Simulating the therapeutic effects of deep brain stimulation in rodents using a cortico-basal ganglia network and volume conductor model. 7th International IEEE/EMBS Conference on Neural Engineering (NER), Montpellier, France, pp. 852 – 855. ISBN: 978-1-4673-6389-1
  Schmidt, C., Dunn, E., Lowery, M. and van Rienen, U.
  
• 2015. The effect of hyperbaric air on the electric activity of neuronal in vitro networks. Biosensors and Bioelectronics, 73, pp. 153-159
  Stubbe, Marco; Nissen, Matthias; Schroeder, Jessica; Gimsa, Jan
  
• 2015. The impact of bone microstructure on the field distribution of electrostimulative implants. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Milano, Italy, pp. 3545 – 3548. ISBN: 978-1-4244-9271-8
  Zimmermann, U. and van Rienen , U.
  
• 2015. Uncertainty quantification for complex RF-Structures using the state-space concatenation approach. 36th Progress in Electromagnetics Research Symposium (PIERS), Prague, Czech Republic, pp. 374 - 378. CERN-ACC-2015-0204
  Heller, J., Flisgen, T., Schmidt, C. and van Rienen, U.
  
• 2016. A comparative study of approaches to compute the field distribution of Deep Brain Stimulation in the Hemiparkinson Rat Model. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Lake Buena Vista (Orlando), USA, pp. 5821-5824
  Böhme, A. and Van Rienen, U
  
• 2016. A novel in vitro system for comparative analyses of bone cells and bacteria under electrical stimulation. BioMed Research International, Epub 2016, pp. 1-12
  Dauben, Thomas Josef; Ziebart, Josefin; Bender, Thomas; Zaatreh, Sarah; Kreikemeyer, Bernd; Bader, Rainer
  
• 2016. A time scale modification with large and varying scaling factors. 2016 IEEE International Symposium on Signal Processing and Information Technology (ISSPIT). IEEE, pp. 193–196. ISBN: 978-1-5090-5844-0
  Struwe, K
  
• 2016. An automatic approach for calibrating dielectric bone properties by combining finite-element and optimization software tools. Computer Methods in Biomechanics and Biomedical Engineering, 19(12), pp. 1306-1313
  Su, Yukun; Kluess, Daniel; Mittelmeier, Wolfram; van Rienen, Ursula; Bader, Rainer
  
• 2016. An implementation for the simulation of cells on micro-post arrays. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Lake Buena Vista (Orlando), USA, pp. 6138–6141
  Truong, D.T., Bahls, C.R., Nebe, J.B. and van Rienen, U.
  
• 2016. Augmented recovery of microorganisms from swabs by homogenization: a novel standardizable high-throughput approach. Diagnostic Microbiology and Infectious Disease, 84 (1), pp. 16–18
  Warnke, Philipp; Redanz, Sylvio; Zaatreh, Sarah; Podbielski, Andreas
  
• 2016. Cell Monitoring and Manipulation Systems (CMMSs) based on Glass Cell-Culture-Chips (GC3s). Micromachines, 7 (7), pp. 1-24
  Buehler, Sebastian M.; Stubbe, Marco; Bonk, Sebastian M.; Nissen, Matthias; Titipornpun, Kanokkan; Klinkenberg, Ernst-Dieter; Baumann, Werner; Gimsa, Jan
  
• 2016. Challenges in Modeling Nerve-Electrode Interactions of Neuronal Implants. International Symposium on Electromagnetic Theory (EMTS), Espoo, Finland, IEEE Conference Publications, pp. 534 – 537
  Appali, R., Sriperumbudur, K. and Van Rienen, U.
  
• 2016. Co-Culture of S. epidermidis and Human Osteoblasts on Implant Surfaces: An Advanced In Vitro Model for Implant-Associated Infections. PloS One.11(3):e0151534
  Zaatreh, Sarah; Wegner, Katharina; Strauß, Madlen; Pasold, Juliane; Mittelmeier, Wolfram; Podbielski, Andreas; Kreikemeyer, Bernd; Bader, Rainer
  
• 2016. Data supporting attempted caveolae-mediated phagpcytosis of surface-fixed micro-pillars by human osteoblasts. Data in Brief, 7, pp. 177–182
  Moerke, Caroline; Mueller, Petra; Nebe, Barbara
  
• 2016. Devitalisation of human cartilage by high hydrostatic pressure treatment: Investigation of subsequent revitalisation with chondrocytes and mesenchymal stem cells. Scientific Reports, 27(6), pp. 1-12
  Hiemer, B.; Genz, B.; Jonitz-Heincke, A.; Pasold, J.; Wree, A.; Dommerich, S.; Bader, R.
  
• 2016. Efficient computation of the neural activation during deep brain stimulation for dispersive electrical properties of brain tissue. IEEE Transactions on Magnetics, 52(3), pp. 1-4
  Schmidt, Christian; Flisgen, Thomas; van Rienen, Ursula
  
• 2016. Enhancing the regeneration of bone defects by alkalizing the peri-implant zone – an in vitro approach. 15th Biennial Conference of the International Society of Fracture Repair, Munich, Germany, 1 page
  Galow, A., Wysotzki, P., Oldorf, P. and Gimsa, J.
  
• 2016. Enhancing the regeneration of bone defects by alkalizing the peri-implant zone – an in vitro approach. Current Directions in Biomedical Engineering, 2(1), pp. 547–551
  Galow, Anne-Marie; Wysotzki, Philipp; Baumann, Werner; Gimsa, Jan
  
• 2016. Field distribution for Deep Brain Stimulation using an anatomical partially anisotropic Volume Conductor Model of the rat brain. 2nd International Conference on Deep Brain Stimulation (DBS), Düsseldorf, Germany, 1 page
  Böhme, A. and van Rienen, U.
  
• 2016. Improving osteoblast cell culture: alkaline pH promotes proliferation and differentiation. 8th Kirkstall Conference, Advances in Cell and Tissue Culture, Barcelona, Spain, 1 page
  Galow, A. and Gimsa, J.
  
• 2016. Magnetically induced electrostimulation of human osteoblasts results in enhanced cell viability and osteogenic differentiation. International Journal of Molecular Medicine, 38 (1), pp. 57-64
  Hiemer, Bettina; Ziebart, Josefin; Jonitz-Heincke, Anika; Grunert, Philip Christian; Su, Yukun; Hansmann, Doris; Bader, Rainer
  
• 2016. Medizinisches Implantat und Verfahren zu Osteoblastenkultivierung. AZ: DE102015220651
  Galow, A., Bonk, S., Wysotzki, P., Baumann, W.
  
• 2016. Micro-topographical surface features interfere with osteoblast cell signaling. 10th World Biomaterial Congress, Montreal, Canada, 1 page
  Moerke, C., Staehlke, S. and Nebe, J.B.
  
• 2016. Neuronal in vitro activity is more sensitive to valproate than intracellular ATP: Considerations on conversion problems of IC50 in vitro data for animal replacement. BioSystems, 144, pp. 35-45
  Nissen, Matthias; Buehler, Sebastian M.; Stubbe, Marco; Gimsa, Jan
  
• 2016. Plasma-deposited fluorocarbon polymer films on titanium for preventing cell adhesion: a surface finishing for temporarily used orthopaedic implants. Journal of Physics: Applied Physics, 49 (23)
  Finke, B.; Testrich, H.; Rebl, H.; Walschus, U.; Schlosser, M.; Zietz, C.; Staehlke, S.; Nebe, J. B.; Weltmann, K. D.; Meichsner, J.; Polak, M.
  
• 2017. APT: Enhanced Speech Comprehension Through Adaptive Pitch Transposition in Cochlear Implants. Springer International Publishing. eHealth 360°, 181, pp. 224-228
  Kevin Struwe
  
• Caveolae-mediated phagocytosis of biomaterial surface structures by osteoblasts. Mathematisch-Naturwissenschaftliche Fakultät
  Caroline Mörke
  
• Funktionelle und morphologische Langzeiteffekte der Tiefen Hirnstimulation mit zwei Elektrodenmodifikationen im 6-OHDA- Hemiparkinson-Modell der Ratte. Mathematisch-Naturwissenschaftliche Fakultät
  Kathrin Badstübner
  
• Zum Einfluss der oberflächennahen elektrischen Feldverteilung an nanostrukturierten Biomaterialoberflächen auf das Biosystem. Fakultät für Informatik und Elektrotechnik
  Andreas Körtge
  
• 2017. Abrogated Cell Contact Guidance on Amino-Functionalized Microgrooves; ACS Applied Materials Interfaces, 9(12), pp. 10461–10471
  Mörke, Caroline; Rebl, Henrike; Finke, Birgit; Dubs, Manuela; Nestler, Peter; Airoudj, Aissam; Roucoules, Vincent; Schnabelrauch, Matthias; Körtge, Andreas; Anselme, Karine; Helm, Christiane A.; Nebe, J. Barbara
  
• 2017. Adaptive Estimation of the Neural Activation Extent in Computational Volume Conductor Models of Deep Brain Stimulation. IEEE Transactions on Biomedical Engineering, (12 pages)
  Schmidt, Christian; van Rienen, Ursula
  
• 2017. Adaptive Pitch Transposition: Smart Auditory Spectral Shifts in Cochlear Implants. Engineering, 9(9), pp. 739–754
  Struwe, Kevin; Salomon, Ralf
  
• 2017. Automated and manual patch clamp data of human induced pluripotent stem cell-derived dopaminergic neurons. Nature Scientific Data, 4:170056
  Franz, Denise; Olsen, Hervør Lykke; Klink, Oliver; Gimsa, Jan
  
• 2017. Biocompatibility and inflammatory potential of titanium alloys cultivated with human osteoblasts, fibroblasts and macrophages. Materials. 10(1), pp. 1-17
  Markhoff, Jana; Krogull, Martin; Schulze, Christian; Rotsch, Christian; Hunger, Sandra; Bader, Rainer
  
• 2017. Characterization of human cancellous and subchondral bone with respect to electro physical properties and bone mineral density by means of impedance spectroscopy. Medical Engineering and Physics, 45, pp. 34-41
  Haba, Yvonne; Wurm, Andreas; Köckerling, Martin; Schick, Christoph; Mittelmeier, Wolfram; Bader, Rainer
  
• 2017. Chondrogenic Differentiation of Human Chondrocytes and Stem Cells in Different Cell Culture Systems Using IGF-1-Coupled Particles. Journal of Tissue Science & Engineering. 8(2), pp.1-10
  B, Hiemer; M, Krogull; K, Zander; C, Gruttner; P, Bergschmidt; T, Tischer; A, Wree; R, Bader; J, Pasold
  
• 2017. Complex cell physiology on topographically and chemically designed material surfaces. Material Science Forum, 879, pp. 78-83
  Nebe, J. Barbara; Moerke, Caroline; Staehlke, Susanne; Finke, Birgit; Schnabelrauch, Matthias; Anselme, Karine; Helm, Christiane A.; Frank, Marcus; Rebl, Henrike
  
• 2017. Copper as an alternative antimicrobial coating for implants - An in vitro study. World Journal of Transplantation, 7(3), pp. 193-202
  Bergemann, Claudia; Zaatreh, Sarah; Wegner, Katharina; Arndt, Kathleen; Podbielski, Andreas; Bader, Rainer; Prinz, Cornelia; Lembke, Ulrich; Nebe, J. Barbara
  
• 2017. Design and Implementation of a Neural Network for Voiced/Unvoiced Classification for a Given System. International Journal of Neural Networks and Advanced Applications, 4, pp. 39–44. ISSN: 2313-0563
  Struwe, K.
  
• 2017. Direct influence of titanium and zirconia particles on the morphology and functionality of mature human osteoclasts. Journal of Biomedical Materials Research: Part A, 105(9), pp. 2608–2615
  Pasold, Juliane; Markhoff, Jana; Tillmann, Jenny; Krogull, Martin; Pisowocki, Phillip; Bader, Rainer
  
• 2017. Evaluating the Vowel Quality of Pitch Adaptation Methods to be used in Cochlear Implants. 40th International Conference on Telecommunications and Signal Processing (TSP). IEEE, pp. 364–367. ISBN: 978-1-5090-3981-4
  Struwe, K
  
• 2017. Fast corroding, thin magnesium coating displays antibacterial effects and low cytotoxicity. Biofouling, 28, pp. 1–12
  Zaatreh, Sarah; Haffner, David; Strauß, Madlen; Wegner, Katharina; Warkentin, Mareike; Lurtz, Claudia; Zamponi, Christiane; Mittelmeier, Wolfram; Kreikemeyer, Bernd; Willumeit-Römer, Regine; Quandt, Eckhard; Bader, Rainer
  
• 2017. Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects In Vivo. Stem Cells International, 2017:3548435, pp. 1-9
  Kämmerer, Peer W.; Scholz, Malte; Baudisch, Maria; Liese, Jan; Wegner, Katharina; Frerich, Bernhard; Lang, Hermann
  
• 2017. Increased osteoblast viability at alkaline pH in vitro provides a new perspective on bone regeneration. Biochemistry and Biophysics Reports, 10, pp.17-25
  Galow, Anne-Marie; Rebl, Alexander; Koczan, Dirk; Bonk, Sebastian M.; Baumann, Werner; Gimsa, Jan
  
• 2017. Influence of analyzed lubricant volumes on the amount and characteristics of generated wear particles from three different types of polyethylene liner materials. Journal of Biomedical Materials Research: Part B – Applied Biomaterials, 106(3), pp. 1-8
  Markhoff, Jana; Zietz, Carmen; Fabry, Christian; Fulda, Gerhard; Bader, Rainer
  
• 2017. Influence of different grained powders and pellets made of Niobium and Ti-42Nb on human cell viability. Materials Science and Engineering: C, 73, pp. 756–766
  Markhoff, Jana; Weinmann, Markus; Schulze, Christian; Bader, Rainer
  
• 2017. Low-Dimensional Stochastic Modeling of the Electrical Properties of Biological Tissues. IEEE Transactions on Magnetics, 53(6), 4 pages
  Romer, Ulrich; Schmidt, Christian; van Rienen, Ursula; Schops, Sebastian
  
• 2017. MC3T3 osteoblast-like cells cultured at alkaline pH: Microarray data (Affymetrix GeneChip Mouse 2.0 ST). Data in Brief, 13, pp. 108-114
  Galow, Anne-Marie; Rebl, Alexander; Koczan, Dirk; Gimsa, Jan
  
• 2017. Numerical design studies on a novel electrostimulative osteosynthesis system for the mandible. Current Directions in Biomedical Engineering, 3(2), pp. 613-617
  Nebe, J. Barbara; Moerke, Caroline; Staehlke, Susanne; Finke, Birgit; Schnabelrauch, Matthias; Anselme, Karine; Helm, Christiane A.; Frank, Marcus; Rebl, Henrike
  
• 2017. Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. PLoS ONE, 12(1), p. 18
  Engel, Nadja; Adamus, Anna; Schauer, Nicolas; Kühn, Juliane; Nebe, Barbara; Seitz, Guido; Kraft, Karin
  
• 2017. The Impact of Metal Ion Exposure on the Cellular Behavior of Human Osteoblasts and PBMCs: In vitro Analyses of Osteolytic Processes. Materials, 10(7), 734
  Jonitz-Heincke, Anika; Tillmann, Jenny; Klinder, Annett; Krueger, Simone; Kretzer, Jan Philippe; Høl, Paul Johan; Paulus, Alexander C.; Bader, Rainer
  
• 2017. Thin magnesium layer confirmed as an antibacterial and biocompatible implant coating in a co-culture model. Molecular Medicine Reports, 15(4), pp. 1624-1630
  Zaatreh, Sarah; Haffner, David; Strauss, Madlen; Dauben, Thomas; Zamponi, Christiane; Mittelmeier, Wolfram; Quandt, Eckhard; Kreikemeyer, Bernd; Bader, Rainer
  
• 2017. Transient supplementation of growth factor TGF-β1 effectively initiates chondrogenic redifferentiation of human chondrocytes. Current Directions in Biomedical Engineering, 3(2), pp. 383–387
  Hiemer, Bettina; Achenbach, Kathleen; Pasold, Juliane; Wree, Andreas; Bader, Rainer
  
• 2017. Voiced-Unvoiced Classification of Speech Using a Neural Network Trained with LPC Coefficients. International Conference on Control, Artificial Intelligence, Robotics & Optimization. IEEE, pp. 56–59. ISBN: 978-1-5090-6537-0
  Struwe, K
  
• 2017. WST-assay data reveal a pH dependence of the mitochondrial succinate reductase in osteoblast-like cells. Data in Brief, 12, pp. 442-446
  Galow, Anne-Marie; Gimsa, Jan
  
• Electro-stimulating implants for bone regeneration: parameter analysis and design optimization. Fakultät für Informatik und Elektrotechnik
  Yukun Su
  
• Elektrochemische DNA-Detektion mit Hilfe eines Hybridisierungsassays: Effekte von Temperatur und Fehlpaarungen. Mathematisch-Naturwissenschaftliche Fakultät
  Katarzyna Biala
  
• Entwicklung von Zellkultursystemen mit integrierter Sensorik und Aktuatorik für die Überwachung von Knochenzellkulturen. Mathematisch-Naturwissenschaftliche Fakultät
  Sebastian Bonk
  
• Experimentelle Charakterisierung antibakterieller Implantatoberflächen mittels Mono- und Kokultur von S. epidermidis und humanen Osteoblasten. Universitätsmedizin Rostock
  Sarah Zaatreh
  
• Mathematische Modelle zur Rekonstruktion von Zellnetzwerken auf Multielektrodenarrays. Mathematisch-Naturwissenschaftliche Fakultät
  Sebastian Hanisch
  
• 2018. Effect of Tissue Heterogeneity on the Transmembrane Potential of Type-1 Spiral Ganglion Neurons: A Simulation Study. IEEE Transactions on Biomedical Engineering 65(3), pp. 658-668
  Sriperumbudur, Kiran Kumar; Pau, Hans Wilhelm; van Rienen, Ursula
  
• 2018. Semi-analytical representation of the activation level in stress fibre directions as alternative to the angular representation in the bio-chemo-mechanical model for cell contractility. Journal of the Mechanical Behavior of Biomedical Materials, 77, pp. 527-533
  Bahls, Christian Rüdiger; Truong, Duy; van Rienen, Ursula
  
• 2018. Spermidine-Induced Attraction of Like-Charged Surfaces Is Correlated with the pH-Dependent Spermidine Charge. Force Spectroscopy Characterization. Langmuir, 34(8), pp. 2725- 2733
  Gimsa, Jan; Wysotzki, Philipp; Perutkova, Šarka; Weihe, Thomas; Elter, Patrick; Marszałek, Piotr; Kralj-Iglič, Veronika; Müller, Torsten; Iglič, Aleš
  
• 2018. Streptavidin-coated surfaces suppress bacterial colonisation by inhibiting non-specific protein adsorption. Journal of Biomedical Materials Research Part A, 106(3), pp. 758-768
  Ettelt, Volker; Ekat, Katharina; Kämmerer, Peer W.; Kreikemeyer, Bernd; Epple, Matthias; Veith, Michael
  
• 2018. Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model. Transactions on Neural Systems & Rehabilitation Engineering, 26(2), pp. 281-290
  Schmidt, Christian; Dunn, Eleanor; Lowery, Madeleine; van Rienen, Ursula
  
• Charakterisierung ausgewählter molekularer und zellulärer Adhäsionsmechanismen an artifiziellen Oberflächen. Mathematisch-Naturwissenschaftliche Fakultät
  Thomas Weihe
  
• Establishment of a novel in vitro implant infection model: effects of electrical stimulation on staphylococci using alternating current. Universitätsmedizin Rostock
  Thomas Dauben
  
• Optimierung von in vitro-Kultursystemen für Knochenzellen – Einfluss von pH und mechanischer Stimulation. Fakultät für Informatik und Elektrotechnik
  Anne-Marie Galow