T cells and cholangiocytes: an interaction that governs portal immune regulation and determines biliary inflammation (A05)

• Subject Area: Gastroenterology ; Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 530990199

The interaction between T cells and cholangiocytes is central to the pathogenesis of cholangiopa-thies. We will identify the bidirectional network between T cells and cholangiocytes in vivo using well-established mouse models and in vitro using murine and human cholangiocyte organoid models. Moreover, we will decipher the antigen presenting capacity of cholangiocytes and characterise the impact of T cells and cytokines on the activation, regeneration and senescence of cholangiocytes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1700: Immune regulation in the liver: from homeostasis to disease
• Applicant Institution: Universität Hamburg
• Project Head: Dr. Dorothee Schwinge