T cells and cholangiocytes: an interaction that governs portal immune regulation and determines biliary inflammation
(A05)
Subject Area
Gastroenterology
Immunology
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 530990199
The interaction between T cells and cholangiocytes is central to the pathogenesis of cholangiopa-thies. We will identify the bidirectional network between T cells and cholangiocytes in vivo using well-established mouse models and in vitro using murine and human cholangiocyte organoid models. Moreover, we will decipher the antigen presenting capacity of cholangiocytes and characterise the impact of T cells and cytokines on the activation, regeneration and senescence of cholangiocytes.
DFG Programme
Collaborative Research Centres
