Modulation of metaflammation by secretory intestinal Immunoglobulin A antibodies in clean mice (P22*)

• Subject Area: Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

Metaflammation induced by high-caloric intake impacts B cell immunity. This results in biased B cell receptor repertoires in systemic and intestinal tissues and, indeed, high-fat diet (HFD)-induced IgG antibodies have been shown to be one factor contributing to the induction of metaflammation. In contrast, intestinal IgA is partly protective in HFD-induced metaflammation, likely by controlling intestinal inflammation and intestinal permeability. Here, we aim to define the targets and functional role of HFD-induced intestinal IgA antibodies on metaflammation without confounder effects induced by different diet compositions or the microbiota.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Tim Rollenske