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Glucocorticoid-mediated immune-metabolic reprogramming of macrophages

Subject Area Immunology
Rheumatology
Term since 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 550772961
 
Our data suggest that Glucocorticoids (GC) promote an increase in pyruvate dehydrogenase activity and a consecutive citrat cycle acceleration in pro-inflammatory macrophages. This GC-induced metabolic reprogramming seems to rely on non-genomic properties of the Glucocorticoidreceptor and results in the exacerbated and sustained production of the anti-inflammatory metabolite itaconate as well as a consecutive inhibition of the inflammatory response in inflammatory macrophages. In the proposed project, we aim to further dissect the molecular mechanisms that control the GC-mediated regulation of pyruvate dehydrogenase and citric acid cycle activity and seek to understand the relevance of these events for the pro-resolving and anti-inflammatory properties of GCs during the treatment of Immune-mediated inflammatory diseases such as rheumatoid arthritis and asthma.
DFG Programme Research Grants
Co-Investigator Dr. Jean-Philippe Auger
 
 

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