Image-guided tumour therapies with CAR T cells co-engineered for local depletion of immunosuppressive macrophages (A07*)

• Subject Area: Hematology, Oncology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

We aim to enable effective T cell targeting of solid cancers by co-engineering T cells with tumour-antigen specific CARs and for local release of an antagonist that selectively depletes immunosuppressive myeloid cell populations in tumour tissues. Our multimodal cellular targeting and imaging strategy will include in vivo tracking of the inflammatory tumour microenvironment, the fate of the CAR T cells and released antagonist along with local tumour growth and dissemination. The insights from this project will inform clinical translation of this novel strategy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Head: Professorin Dr. Claudia Rössig