The Collaborative Research Centre aims at analysing the dynamics of complex multiprotein systems that cause folding, intracellular transport and specific localisation of macromolecules. Dynamics are of interest i) at a cell biological level to describe the formation of higher complexes by protein/protein, protein/nucleic acid, and protein lipid interactions central for all projects of the program, and ii) with respect to the kinetics of changes within such individual complexes, e.g. their conformational change, polymerisation or formation of subcomplexes. This aspect will be analysed by biochemical/biophysical methods in some of the projects. A complementation and extension of topics is reached specifically by combining virological and molecular cell biological projects within a mutual initiative. Synergetic effects will arise from similar concepts and questions asked in these fields of biological research.
DFG Programme
Collaborative Research Centres
Completed projects
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A01 - Mechanism of action of ribosome-associated chaperones in co-translational folding and transport of proteins
(Project Heads
Bukau, Bernd
;
Kramer, Günter
)
-
A02 - Signal peptides and the insertion of TA proteins into te membrane of the endoplasmic reticulum
(Project Head
Dobberstein, Bernhard
)
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A03 - Structure and Dynamics of Protein/RNA complexes in SRP-mediated protein transport
(Project Heads
Sinning, Irmgard
;
Wild, Klemens
)
-
A04 - Mechanismus und Regulation der ER-Lokalisation durch Arginin-Signale
(Project Head
Schwappach-Pignataro, Blanche
)
-
A05 - Biogenesis, Structure and Dynamics of flaviviral replication complexes
(Project Head
Bartenschlager, Ralf Friedrich Wilhelm
)
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A07 - Biogenese von Peroxisomen
(Project Head
Just, Wilhelm
)
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A08 - Unconventional Protein Secretion
(Project Head
Nickel, Walter
)
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A09 - Formation and dynamic alterations of retroviral transport, assembly and budding complexes
(Project Head
Kräusslich, Hans-Georg
)
-
A10 - Dynamics of COPI Assembly
(Project Heads
Brügger, Britta
;
Wieland, Felix Wilhelm Theodor
)
-
A11 - Modulation of architecture and function of the immunological synapse by the HIV pathogenesis factor Nef
(Project Head
Fackler, Ph.D., Oliver T.
)
-
A13 - Mechanism and dynamics of Hsp70 and Hsp90-assisted folding of Transcription factors and kinases
(Project Head
Mayer, Matthias Peter
)
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A15 - Koordination und Regulation der homotypischen Fusion von Hefevakuolen; Mechanismus und Funktion der Palmitoylierung von Fusionsfaktoren
(Project Head
Ungermann, Christian
)
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A16 - Structural dynamics of coatomer
(Project Heads
Briggs, John
;
Wieland, Felix Wilhelm Theodor
)
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A18 - Structure and dynamics of the protein O-mannosylation machinery
(Project Head
Strahl, Sabine
)
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A19 - Structure and dynamics of protein complexes in tail-anchored membrane protein biogenesis
(Project Head
Sinning, Irmgard
)
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B01 - Transportprozesse zwischen Zellkern und Zytoplasma
(Project Head
Görlich, Dirk
)
-
B02 - Structure, Function and Reconstitution of the Nuclear Pore Complex
(Project Heads
Flemming, Dirk
;
Hurt, Eduard Christian
)
-
B03 - Formation, Maturation and Nuclear Export of mRNPs
(Project Head
Hurt, Eduard Christian
)
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B04 - Temporal and spatial dynamics of the circadian clock of Neurospora
(Project Head
Brunner, Michael
)
-
B05 - Regulation of complexes involved in spindle positioning
(Project Head
Liakopoulos, Ph.D., Dimitris
)
-
B07 - Nuclear envelope insertion of the yeast centrosome
(Project Head
Schiebel, Elmar
)
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B08 - Sumoylation of nuclear transport receptors
(Project Head
Melchior, Frauke
)
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B09 - Coupling of RNA quality control to nuclear export
(Project Head
Fischer, Tamás
)
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NW01 - Regulation of complexes involved in spindle positioning
(Project Head
Liakopoulos, Ph.D., Dimitris
)
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Z01 - Protein analysis by mass spectrometry
(Project Heads
Lechner, Johannes
;
Ruppert, Thomas
)
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Z02 - Central tasks of the Collaborative Research Centre
(Project Head
Wieland, Felix Wilhelm Theodor
)
-
Z03 - Flow Cytometry/Fluorescence Activated Cell Sorting (FACS)
(Project Heads
Knop, Michael
;
Sourjik, Victor
)
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Z04 - HTP-Protein crystallization platform and X-ray structure determination
(Project Head
Sinning, Irmgard
)
