SFB 575:  Experimental Hepatology

• Subject Area: Medicine
• Term: from 2001 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5484543

Due to high morbidity and mortality liver diseases are of extraordinary social and economical interest. The aim of this collaborative research centre 575 is to gain new insights into the function of the normal liver and the molecular mechanisms underlying liver damage leading to clinical symptoms. Thereby a panel of methods ranging from molecular and cell biological techniques to modern in vivo imaging is applicated. Special attention is given to the complex communication between different liver cell types and the involved mechanisms of inter- and intracellular signal transduction. Exemplified with the hepatic encephalopathy the pathomechanism of an extrahepatic manifestation of liver cirrhosis will be examined. The results may allow the development of new strategies for the treatment of liver disease.

• DFG Programme: Collaborative Research Centres

Completed projects

• A01 - Hepatobiliary transport and signaling proteins (Project Head Kubitz, Ralf J. )
• A02 - Sorting von ABC-Transportern in Hefe und Leberzellen (Project Head Kölling, Ralf )
• A03 - Osmosensing and osmosignaling in the liver (Project Head Reinehr, Roland )
• A04 - Mechanisms of hydration-dependent hormone and cytokine resistance (Project Heads Bode, Johannes Georg ;  Häussinger, Dieter ;  Schliess, Freimut )
• A05 - Die Regulation des Proteinabbaus in der Leber (Project Head vom Dahl, Stephan )
• A06 - Die Rolle der VPS4-Proteine bei der Proteolyse in der Leber (Project Head Köhrer, Karl )
• A08 - G-protein-dependent regulation of autophagy (Project Head Gohla, Antje )
• A09 - In vitro characterization of ABC-transporters in human liver (Project Head Schmitt, Lutz )
• A10 - Role of the membrane-bound bile salt receptor TGR5 in the liver (Project Head Keitel-Anselmino, Verena )
• B01 - Activating and apoptotic processes in liver (Project Head Häussinger, Dieter )
• B2 - Zytoprotektion und Immunsuppression durch hepatische Expression der induzierbaren NO-Synthase (Project Head Kolb-Bachofen, Victoria )
• B03 - Modulation of Jak/STAT-mediated signal-transduction in the liver (Project Head Bode, Johannes Georg )
• B04 - Modulation and regulation of gap junctional intercellular communication in the liver (Project Heads Klotz, Lars-Oliver ;  Sies, Helmut )
• B05 - Leberschädigung und Leberregeneration: Regulation durch Osmolyte und Zellhydratation (Project Head Wettstein, Markus )
• B6 - Bedeutung des ALR-Proteins bei der Leberregeneration (Project Heads Hofhaus, Götz ;  Lisowsky, Thomas )
• B07 - Die Rolle von NF-KB und MAP-Kinase Signalwegen in der Proliferation und entzündlichen Antwort von Hepatozyten (Project Head Ludwig, Stephan )
• B08 - Role of the novel IêB protein IêB-æ in the liver (Project Heads Jänicke, Reiner U. ;  Schulze-Osthoff, Klaus ;  Totzke, Gudrun )
• B09 - The role of TNF recptor p55 (TNFRp55) for liver failure during acute sepsis and bacterial infections (Project Heads Beer-Hammer, Sandra ;  Pfeffer, Klaus )
• B10 - Pathogenetische Bedeutung der Betaindepletion für die Hepatopathie bei Hyperhomocyssteinämie (Project Heads Mayatepek, Ertan ;  Schwahn, Bernd Christian )
• B11 - Structural characterisation of host cell signalling pathway modulation by the hepatitis C virus protein NS5A (Project Heads Hoffmann, Silke ;  Willbold, Ph.D., Dieter )
• B12 - Analyse STAT-vermittelter hepatozellulärer Signalwege mittels viraler Antagonisten (Project Head Hengel, Hartmut )
• B13 - Modulation of hepatic acute phase reaction and antiviral response by pro-apaptotic substances (Project Head Graf, Dirk )
• B14 - Pathophysiological basis of hepatopathy in inborn defects of fatty acid oxidation (Project Heads Mayatepek, Ertan ;  Spiekerkötter, Ute )
• B15 - Regulation of energy metabolism and lipid depostion in non-alcoholic fatty liver disease and insulin resistance (Project Head Roden, Michael )
• C01 - Hydration-dependent regulation of astrocyte function (Project Heads Häussinger, Dieter ;  Schliess, Freimut )
• C2 - Störungen der zerebralen zellulären Volumenregulation: Ursachen, funktionelle Konsequenzen und Bedeutung für die hepatische Enzephalopathie (Project Head Witte, Otto Wilhelm )
• C03 - Transmitter and Oscillations in hepatic encephalopathy (Project Heads Haas, Helmut L. ;  Selbach, Oliver ;  Sergeeva, Olga )
• C04 - Neurophysiological mechanisms of cognitive dysfunction in hepatic encephalopathy (Project Heads Kircheis, Gerald ;  Schnitzler, Alfons )
• C05 - Disturbances of Water Concentration and Osmolyte Homoeostasis in Hepatic Encephalopathy (Project Heads Häussinger, Dieter ;  Shah, Ph.D., Nadim Jon ;  Zilles, Karl )
• C06 - Proteinoxidation und intrazellulärer Proteinabbau in Astrozyten bei hepatischer Enzephalopathie (Project Head Grune, Tilman )
• C07 - Intra- und extracellular ion changes following hepatic encephalopathy (Project Head Rose, Christine R. )
• C08 - Gabaergic tone in hepatic encephalopathy (Project Head Sergeeva, Olga )
• MGK - Integrated Research Training Group "Experimental Hepatology" (Project Heads Haas, Helmut L. ;  Reinehr, Roland )
• V01 - Investive Maßnahmen und Tiermodelle (Project Head Häussinger, Dieter )
• V02 - Administration (Project Head Häussinger, Dieter )

• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Participating Institution: Forschungszentrum Jülich
• Spokesperson: Professor Dr. Dieter Häussinger