Membrane remodelling during mitochondrial lipid transfer (P08)

• Subject Area: Biochemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 511488495

Mitochondria are major sites of cellular lipid biosynthesis. The mitochondrial signature lipid cardiolipin is synthesized in the mitochondrial inner membrane. This process depends on the import of phosphatidic acid, which is transported from the mitochondrial outer to the inner membrane by the lipid transfer protein complex Ups1/Mdm35. In this project we will decipher how the physico-chemical characteristics of the membrane and the oligomeric state of the protein complex, influence protein-membrane interaction, allow the extraction and insertion of a lipid from and into membranes and determine the specific direction of lipid transfer.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1638: Cellular membrane remodelling – how changing form creates function
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Michael Meinecke