SPP 1085: Zelluläre Mechanismen der Alzheimer Erkrankung
Fachliche Zuordnung
Medizin
Förderung
Förderung von 2000 bis 2006
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5469986
Projektbeschreibung
Keine Zusammenfassung vorhanden
DFG-Verfahren
Schwerpunktprogramme
Internationaler Bezug
Frankreich
Projekte
A reverse genetic approach to define physiologically important functional domains of APP family proteins: analysis in APP/APLP knockout mice
(Antragstellerin
Müller, Ulrike
)
Alzheimer Amyloid Precursor Protein cleavage regulation by Gangliosides
(Antragsteller
Hartmann, Tobias
)
APP, APLPs and BACE: Substrate-enzyme interaction in a high molecular weight complex
(Antragsteller
Multhaup, Gerhard
)
APP-Processing
(Antragsteller
Merdes, Gunter
)
Approaches for upregulation of the alpha-secretase and elucidation of its role in differentiation and Abeta homeostasis
(Antragsteller
Fahrenholz, Falk
)
Cellular function of the amyloid precursor like protein 1 in endocytosis and proteolytic shedding of APP
(Antragsteller
Lichtenthaler, Stefan
)
Die Rolle der Proteoglykane im zellulären Metabolismus der ßAmyloid Peptide
(Antragsteller
März, Winfried
)
Die Rolle von Sphingolipid-Cholesterin Mikrodomänen (Rafts) beim Transport und Prozessierung des Amyloid-Vorläuferproteins
(Antragsteller
Simons, Kai
)
Effects of cholesterol and glia-derived lipoproteins on survival, growth and synaptic differentiation of highly purified neurons from different regions of the mouse brain
(Antragsteller
Pfrieger, Frank W.
)
Functional analysis of axonal transport vesicles containing APP, APLP1 or APLP2
(Antragsteller
Kins, Stefan
)
Functional dissection of presenilins in a C. elegans in vivo model
(Antragsteller
Baumeister, Ralf
)
Identification and functional characterization of neuroprotective signaling mechanisms and of target genes that mediate the selective resistance of neuronalcells against Alzheimer`s Disease-associated oxidative nerve cell death
(Antragsteller
Behl, Christian
)
Interactions and functional analysis of normal and PHF-like mutated tau proteins as a model for tau pathology in Alzheimer`s disease
(Antragsteller
Brandt, Roland
)
Metabolismus von APP und Aß im Endoplasmatischen Retikulum: Die mögliche Bedeutung für die Regulation von Apoptose und Antiapoptose bei der Alzheimerschen Erkrankung
(Antragsteller
Herzog, Volker
)
Molecular Mechanisms in the Regulation of Metabolism and Biological Functions of the ß-Amyloid Precursor Protein
(Antragsteller
Walter, Ph.D., Jochen
)
Molecular Mechanisms of Presenilin Function
(Antragsteller
Haass, Christian
)
PHF-aggregation and microtubule interactions of tau mutants
(Antragsteller
Mandelkow, Eckhard
)
Protease inhibition and imaging of amyloid assemblies
(Antragsteller
Schmidt, Boris
)
Protein-protein and protein-lipid interactions of the ß-amyloid precursor protein during membrane trafic in neurosecretory cells
(Antragsteller
Huttner, Wieland B.
)
Selective neuronal cell death in Alzheimer`s disease: role of apolipoprotein E4,P/Q type Ca2+-channels and oxidative stress in entorhinal cortex layer II stellate cells
(Antragstellerin
Grantyn, Rosemarie
)
Steroid Hormone Regulation of Alzheimer ß Amyloid Precursor and Tau Proteins
(Antragsteller
Almeida, Osborne
)
Structure, supramolecular association and interaction of patho-active presenilin and betaAPP domains by high resolution mass spectrometry
(Antragsteller
Przybylski, Ph.D., Michael
)
Tau and intracellular transport
(Antragstellerin
Mandelkow, Eva-Maria
)
Tau-Modification and Oxidative Stress
(Antragsteller
Grune, Tilman
)
The cellular basis of APP processing: trafficking and assembly of gamma-secretases and its substrates
(Antragsteller
Haass, Christian
)
The Role of Phosphorylation in the Regulation of Presenilin Functions
(Antragsteller
Walter, Ph.D., Jochen
)
The role of the members of the LDL receptor family in the cellular metabolism of ß amyloid peptides
(Antragsteller
März, Winfried
)
To unravel the spatio-temporal profile, function(s) and molecular partners of y-secreatase activity during vertebrate embryogenesis, using the zebrafish as a simple in vivo model system
(Antragstellerin
Bally-Cuif, Laure
)
Sprecher
Professor Dr. Christian Haass
;
Professor Dr. Gerhard Multhaup
