Systematic analysis of ER-shaping Reticulon and REEP proteins (P01)

To understand how the complex architecture of the ER is generated, we propose to systematically analyze the major ER membrane-shaping proteins of the Reticulon and REEP families. We will first characterize their molecular environments, second determine their precise localization in cells and third investigate their functions by a targeted degradation approach. This work will help to elucidate how different ER subdomains are established and enable the various functions of the organelle.

DFG Programme Collaborative Research Centres

Subproject of SFB 1638:  Cellular membrane remodelling – how changing form creates function

Applicant Institution Ruprecht-Karls-Universität Heidelberg

Project Head Dr. Anne-Lore Schlaitz