Die Bedeutung von Lysophospholipiden und ihrer EDG-Rezeptoren für die Myokardprotektion

• Applicant: Professor Dr. Bodo Levkau
• Subject Area: Anatomy and Physiology
• Term: from 2005 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5442745

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• High-density lipoproteins and their constituent S1P directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 sphingolipid receptor. Circulation 2006; 114:1403-9
  Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, von Wnuck Lipinski K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau B
  
• HDL and its sphingosine-1-phosphate content in cardioprotection. Heart Fail Rev. 2007; 12:301-6
  Keul P, Sattler K, Levkau B
  
• Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. Cardiovasc Res. 2009; 82(2):201-11
  Sattler K, Levkau B
  
• Sphingosine-1-Phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR4-Dependent Signaling Pathway via the S1P3 Receptor. Arterioscler Thromb Vasc Biol. 2007; 27:275-82
  Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J
  
• HDL-associated lysophospholipids inhibit NAD(P)H oxidasedependent monocyte chemoatractant protein-1 (MCP-1) production in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008; 28:1542-8
  Tölle M, Pawlak A, Schuchardt M, Kawamura A, Tietge U J, Levkau B, Lorkowski S, Keul P, Assmann G, Chun J, van der Giet M and Nofer J-R
  
• High high-density lipoprotein-cholesterol reduces risk and extent of percutaneous coronary intervention-related myocardial infarction and improves long-term outcome in patients undergoing elective percutaneous coronary intervention. Eur Heart J. 2009; 30:1894-902
  Sattler KJ, Herrmann J, Yün S, Lehmann N, Wang Z, Heusch G, Sack S, Erbel R, Levkau B