Signalwege der Eliminierung dendritischer Zellen durch Apoptose

• Antragsteller: Professor Dr. Martin Leverkus (†)
• Fachliche Zuordnung: Dermatologie
• Förderung: Förderung von 2004 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5416348

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• 2003. MHC class II-media ted apoptosis in dendritic cells: a role for membrane-associated and mitochondrial signaling pathways. Int. Immunol. 15:993-1006
  Leverkus, M., A.D.McLellan, M.Heldmann, A.O.Eggert, E.B.Brocker, N.Koch, and E.Kampgen
  
• 2003. Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation. Mol. Cell Biol. 23:777-790
  Leverkus, M., M.R.Sprick, T.Wachter, T.Mengling, B.Baumann, E.Serfling, E.B.Brocker, M.Goebeler, M.Neumann, and H.Walczak
  
• 2003. TRAIL-induced apoptosis and gene induction in HaCaT keratinocytes: differential contribution of TRAIL receptors 1 and 2. J Invest Dermatol 121:149-155
  Leverkus, M., M.R.Sprick, T.Wachter, A.Denk, E.B.Brocker, H.Walczak, and M.Neumann
  
• 2004. cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes. J. Biol. Chem. 279:52824-52834
  Wachter, T., M.Sprick, D.Hausmann, A.Kerstan, K.McPherson, G.Stassi, E.B.Brocker, H.Walczak, and M.Leverkus
  
• 2004. NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. J. Cell Biol. 166:369-380
  Kreuz, S., D.Siegmund, J.J.Rumpf, D,Samel, M.Leverkus, O.Janssen, G.Hacker, O.Dittrich-Breiholz, M.Kracht, P.Scheurich, and H. Wajant
  
• 2005. Death receptor-induced signaling pathways are differentially regulated by gamma Interferon upstream of caspase 8 processing. MoL Cell Biol. 25:6363-6379
  Siegmund, D., A. Wicovsky, I.Schmilz, K.Schulze-Osthoff, S.Kreuz, M.Leverkus, O.Dittrich-Breiholz, M.Kracht, and H.Wajant
  
• 2006. Yersinia YopP-induced apoptotic cell death in murine dendritic cells is partially independent from action of caspases and exhibits necrosis-like features. Apoptosis. 11:1959-1968
  Grobner, S., S.E.Autenrieth, I.Soldanova, D.S.Gunst, M.Schaller, E.Bohn, S.Muller, M.Leverkus, S.Wesselborg, I.B.Autenrieth, and S.Borgmann
  
• 2007. IAP antagonists target cIAPl to induce TNFalpha-dependent apoptosis. Cell 131:682-693
  Vince, J.E., W.W.Wong, N.Khan, R.Feltham, D.Chau, A.U.Ahmed, C.A.Benetatos, S.K.Chunduru, S.M.Condon, M.McKinlay, R.Brink, M.Leverkus, V.Tergaonkar, P.Schneider, B.A.Callus, F.Koentgen, D.L.Vaux, and J.Silke