The role of intergenic transcripts in the epigenetic control of rRNA gene transcription

• Antragstellerin: Professorin Dr. Ingrid Grummt
• Fachliche Zuordnung: Zellbiologie
• Förderung: Förderung von 2002 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5370138

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J. (2002) 21. 4632-4640
  Zhou, Y., Santoro, R., and Grummt, I.
  
• The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nature Genet. (2002) 32, 393-396
  Santoro, R., Li, J., and Grummt, I.
  
• Epigenetic control of ribosomal RNA gene transcription. Nature Rev. Mol. Cell. Biol. (2003) 4. 641-649
  Grummt, I. and Pikaard, C.S.
  
• Interactions with the chromatin remodeling complex NoRC facilitates DNA binding of TTF-I. Nucl. Acids Res. (2004) 32, 4091-4099
  Nemeth, A., Strohner, R., Grummt, I., Längst, G.
  
• Silencing of ribosomal genes by targeted recruitment of the nucleolar chromatin remodeling complex NoRC. Mol. Cell. Biol. (2004)24, 1791-1798
  Strohner, R., Nightingale, K.P., Nemeth, A., Grummt, I., Becker, P., Längst, G.
  
• Epigenetic mechanisms of rDNA silencing: Temporal order of NoRC recruitment, histone deacetylation, chromatin remodeling and DNA methylation. Mol. Cell. Biol. (2005) 25, 2539-2546
  Santoro, R. and Grummt, I.
  
• The chromatin remodeling complex NoRC controls replication timing of ribosomal RNA genes. EMBO J. (2005) 24, 120-127
  Li, Y., Santoro, R., Grummt, I.
  
• The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Current Biol. (2005) 15, 1434-1438
  Zhou, Y., Grummt, I.
  
• NoRC-dependent nucleosome positioning silences rRNA genes. EMBO J. (2006) 25, 5735-5741
  Li, J., Längst, G., Grummt, I.
  
• Nuclear myosin 1 and WSTF-ISWI chromatin remodeling complex binds to rDNA to promote rRNA transcription. EMBO Rep. (2006) 7, 525-530
  Percipalle, P. Fomproix, N., Cavellan, E., Voit, R., Reimer, G., Krügher, T, Thyberg, J., Scheer, U., Grummt, I., Ostlund-Farrants, A.-K.
  
• Activation of RNA polymerase I transcription by Cockayne Syndrome group B (CSB) protein and histone methyltransferase G9a. Mol. Cell (2007) 27, 585-595
  Yuan, X., Feng, W., Imhof A., Grummt, I., Zhou, Y.
  
• Development of a species-specific RNA polymerase 1-based shRNA expression vector. Nucl. Acids Res. (2007) 35, e10
  Brenz-Verca, M.S., Weber, P., Mayer, C., Graf C., Refojo, D., Kühn, R., Grummt, I., Lutz, B.
  
• Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Human Mol. Gen. (2007) 16, R21-27
  Grummt, I.
  
• Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells. Nucl. Acids Res. (2007) 35, 2191-2198
  Espada, J., Ballestar, E., Santoro, R., Fraga, M., Villar-Garea, A., Nemeth, A., Moreno, V., Juarranz, A., Längst, G., Grummt, I., Bickmore, W., Esteller, M.
  
• A metabolic throttle regulates the epigenetic state of rDNA. Cell (2008) 133, 577-580
  Grummt, I. and Ladurner, A.G.
  
• Specific interaction of a chromatin remodeling complex with a conserved structure within a small non-coding RNA. EMBO Rep. (2008) 9, 774- 780
  Mayer, C., Neubert, M., Grummt, I.
  
• The epigenetics of rRNA genes, from molecular to chromosome biology. Ann. Rev. Cell Dev. Biol. (2008)24, 131-157
  McStay, B. and Grummt, I.
  
• TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of active genes leading to DNA demethylation. Mol. Cell (2009) 33, 344-353
  Schmitz, K.M., Schmitt, N., Hoffmann-Rohrer, U. Schäfer, A., Grummt, I., Mayer. C