Immunological dissection of cell death-induced inflammation in human disease (A14*)

• Subject Area: Immunology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233

Human genetic studies started to provide evidence that deregulation of cell death programs may provoke intractable systemic inflammation in patients, although the underlying immunological mechanisms are unclear. The aim of this project is to investigate the immunological pathomechanisms of cell death-induced inflammation by establishing a novel animal model for CRIA (cleavage-resistant RIPK1 induced autoinflammation) syndrome, a genetic condition caused by gain-of-function mutations in RIPK1.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1403: Cell Death in Immunity, Inflammation and Disease
• Applicant Institution: Universität zu Köln
• Project Head: Hirotsugu Oda, Ph.D.