Microproteins encoded by “non-coding” RNAs in vascular disease (A10*)

• Subject Area: Anatomy and Physiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255

We have succeeded in identifying the endothelial cell microproteome, including microproteins derived from lncRNAs (lnc-miPs). In this project we will characterize the coding and non-coding function of two endothelial cell lncRNAs, whose expression is altered in response to vascular inflammation. We will also determine the microproteome of contractile and secretory vascular smooth muscle cells from patients with vascular disease and study the impact of interfering with the expression of novel vascular smooth muscle cell lnc-miPs in monoculture and an artery-on-a-chip model.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 267: Non-coding RNA in the cardiovascular system
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Professorin Ingrid Fleming, Ph.D.