Personalized Glioblastoma treatment fuided by patient-derived tumor organoids (A08*)

This project leverages recently established human glioblastoma organoid models to lay the groundwork for future molecularly stratified studies. We will integrate patient-derived organoids to drug screening pipelines to complement druggable target prioritization from molecular profiling. Using single-cell genomics, we will longitudinally map the clonal evolution of treatment-sensitive and resistant organoids to dissect the genetic and transcriptional mechanisms of resistance.

DFG Programme Collaborative Research Centres

Subproject of SFB 1389:  Understanding and Targeting Resistance in Glioblastoma (UNITE Glioblastoma)

Applicant Institution Ruprecht-Karls-Universität Heidelberg

Project Heads Privatdozentin Dr. Aurélie Ernst; Hai-Kun Liu, Ph.D.