Modelling and decoding the mechanisms of left ventricular non compaction cardiomyopathy (A04)

Subject Area Cardiology, Angiology
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253
 

Project Description

Human left ventricular non-compaction cardiomyopathy (LVNC-CM) is a common, yet understudied, heart disease. Many LVNC-CM mutations impact developmental genes, including lamin A, suggesting that these cardiomyopathies have a developmental origin. Here, state-of-the-art 3D left-ventricle organoids and genome engineering are combined to model lamin A mutations. The impact of patient mutations on the differentiation and function of the left ventricle will be characterized using single-cell genomics. The impact of stress on the contractile properties of mutant organoids will be assessed. A04 will thereby reveal the mechanisms by which lamin A mutations predispose and induce LVNC disease.
DFG Programme Collaborative Research Centres
Subproject of SFB 1550:  Molecular Circuits of Heart Disease
Applicant Institution Ruprecht-Karls-Universität Heidelberg
Project Head Eileen E. M. Furlong, Ph.D.