Interplay between epigenetics and metabolism in cardiac laminopathies (A03)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253

Mutations in LMNA cause dilated cardiomyopathy characterized by severe cardiac dysfunction and fatal ventricular arrhythmias, referred to as cardiac laminopathy. We recently found that lamin A-chromatin interactions control the expression of key metabolic enzymes, thereby enabling cardiovascular cells to adjust their metabolic needs. Importantly, Lmna-deficiency resulted in alterations of chromatin accessibility coupled to major changes in metabolites that modulate chromatin structure. The objective of the proposed research program is to decipher the role of lamin A in the crosstalk between epigenetics and metabolism in the pathogenesis of cardiac laminopathy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1550: Molecular Circuits of Heart Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Gergana Dobreva