Function and modulation of genomic cardiomyopathy enhancers (A02)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253

This project investigates cardiomyocyte enhancer-dependent molecular circuits of heart disease, with a focus on enhancers bound by the key cardiac transcription factor GATA4. We will use CRISPR-mediated epigenetic perturbation to dissect the functional contribution of cardiomyocyte enhancers and to modulate pathophysiological processes in vitro an in vivo. Doing so, will decode the impact of sequence context and TF-cooperativity on enhancer activity to identify the mechanistic basis of non-coding genetic risk factors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1550: Molecular Circuits of Heart Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Ralf Gilsbach