Studying inborn errors of immunity affecting neutrophil granulocytes (B01)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

The recruitment and host defence functions of neutrophil granulocytes critically depend on the tightly controlled reorganization of the actin network. In our discovery pipeline for children with inborn errors of immunity, we recently identified novel genetic variants in three actin-regulatory genes: FSCN, MIGFILIN, and ARHGEF6. The clinical phenotypes are variable, ranging from neutropenia to a hyper-inflammatory syndrome. In the present proposal we aim to identify the molecular and cellular pathophysiological mechanisms underlying these newly defined inborn errors of immunity.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Christoph Klein, since 7/2022