Targeting mitochondrial metabolism in pemphigoid diseases (B06)

• Subject Area: Dermatology ; Clinical Immunology and Allergology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335

The decline of mitochondrial metabolism in lymphocytes is tightly correlated with age due to an accumulation of mutations in the mitochondrial genome. Pemphigoid diseases (PDs) are typical autoimmune diseases of the elderly. However, it remains unknown how mitochondrial metabolism controls autoimmunity in PDs. In this project, we aim to define the regulatory circuits that connect mitochondrial metabolism, immune cell signaling and their effector functions in PDs and explore, if pharmacological modulation of selected mitochondrial pathways is a feasible strategy to treat the immunopathology in PD patients.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1526: Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
• Applicant Institution: Universität zu Lübeck
• Project Heads: Dr. Misa Hirose; Martin Väth, Ph.D.