Cell subset-specific roles of FcRn in regulating autoantibody generation and activity in pemphigoid diseases (A07)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335

Immunoglobulin G (IgG) autoantibodies are major drivers of inflammation and tissue destruction in pemphigoid diseases. While lowering IgG half-life via generally blocking FcRn function is a promising strategy to diminish autoantibody pathology, this approach is non-selective and also results in a reduction of protective antibody species. Thus, the main goal of project A07 is to understand to what extent cellular neighbourhoods in the skin, consisting of immune and non-immune cells, contribute to autoantibody-triggered skin pathology via FcRn. Understanding FcRn function locally may allow a more specific targeting of FcRn in the future.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1526: Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
• Applicant Institution: Universität zu Lübeck
• Project Head: Professor Dr. Falk Nimmerjahn