Connecting the gut microbiota to the cardiorenal axis in HFpEF (A10)

• Subject Area: Biochemistry ; Epidemiology and Medical Biometry/Statistics
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 437531118

Chronic kidney disease (CKD) may contribute to the development of HFpEF, but the underlying mechanisms are poorly understood. The subproject investigates the importance of CKD-associated microbiota and microbial metabolites for inflammation and cardiac remodelling. In order to specifically investigate the role of the microbiota and its metabolites, we use in particular gnotobiotic mouse models, microbiota transfers and metabolite treatments. Thus, this subproject will make an important contribution to the understanding of the heart-kidney axis and mechanistically investigate the role of the microbiome as a link between these important organs in HFpEF.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1470: Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Head: Privatdozent Dr. Nicola Wilck