Tumor heterogeneity and genomic instability in classical Hodgkin lymphoma (C01)

Subject Area Immunology
Hematology, Oncology
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 455784452
 

Project Description

Hodgkin lymphoma is a unique B cell lymphoma regarding the phenotypic heterogeneity of the Hodgkin and Reed-Sternberg (HRS) lymphoma cells, the extent of chromosomal abnormalities, and the occurrence of bi-/multinucleated lymphoma cells. We plan an in-depth analysis of the transcriptomic and epigenetic heterogeneity of single HRS cells, as well as of the genetic heterogeneity and instability of these cells. Furthermore, we plan to uncover the mechanisms causing the generation of bi-/multinuclear lymphoma cells. A comparative analysis of diffuse large B cell lymphomas will uncover common and distinct mechanisms of genetic instability and tumor heterogeneity in these lymphomas.
DFG Programme Collaborative Research Centres
Subproject of SFB 1530:  Elucidation and targeting of pathogenic mechanisms in B cell malignancies
Applicant Institution Universität zu Köln
Project Head Professor Dr. Ralf Küppers