Tumor heterogeneity and genomic instability in classical Hodgkin lymphoma (C01)

Hodgkin lymphoma is a unique B cell lymphoma regarding the phenotypic heterogeneity of the Hodgkin and Reed-Sternberg (HRS) lymphoma cells, the extent of chromosomal abnormalities, and the occurrence of bi-/multinucleated lymphoma cells. We plan an in-depth analysis of the transcriptomic and epigenetic heterogeneity of single HRS cells, as well as of the genetic heterogeneity and instability of these cells. Furthermore, we plan to uncover the mechanisms causing the generation of bi-/multinuclear lymphoma cells. A comparative analysis of diffuse large B cell lymphomas will uncover common and distinct mechanisms of genetic instability and tumor heterogeneity in these lymphomas.

DFG Programme Collaborative Research Centres

Subproject of SFB 1530:  Elucidation and targeting of pathogenic mechanisms in B cell malignancies

Applicant Institution Universität zu Köln

Project Head Professor Dr. Ralf Küppers