Understanding the role of cFLIP in B cell lymphoma pathogenesis (A05)

• Subject Area: Immunology ; Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 455784452

Mutations that impair B lymphocyte death lead to immune disorders, including lymphadenopathy, splenomegaly and B cell lymphoma. cFLIP is a key cell death inhibitor whose elevated expression has been frequently associated with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL) and correlates with tumor progression and poor clinical outcome. However, the exact role of cFLIP in B-cell biology and lymphomagenesis has not been elucidated, yet. The major objective of this project is to characterize the role of cFLIP in the pathogenesis and progression of DLBCL and determine how its inhibition could be exploited for the treatment of lymphoma.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1530: Elucidation and targeting of pathogenic mechanisms in B cell malignancies
• Applicant Institution: Universität zu Köln
• Project Head: Alessandro Annibaldi, Ph.D.