Adrenergic regulation of myeloid cells in chronic inflammation and neurodegeneration (B17*)

Neuronal regulation of immune cell function is emerging as a critical regulator of chronic inflammationand neurodegeneration. In this context, the β2-adrenergic receptor (Adrb2) on myeloid cells waslinked to the pathogenesis of chronic inflammatory diseases. We propose to systematically investigateimmune regulation by Adrb2 using conditional deletion of Adrb2 in neutrophils, macrophages, anddendritic cells. These conditional knockout mice will be combined with disease models, nextgenerationsequencing and the modulation of neuronal activation to dissect the molecular pathwaysthat regulate chronic inflammation.

DFG Programme CRC/Transregios

Subproject of TRR 167:  Development, function and potential of myeloid cells in the central nervous system (NeuroMac)

Applicant Institution Albert-Ludwigs-Universität Freiburg

Project Head Professor Dr. Christoph Siegfried Niki Klose