Adrenergic regulation of myeloid cells in chronic inflammation and neurodegeneration (B17*)

Subject Area Molecular and Cellular Neurology and Neuropathology
Term from 2021 to 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024
 

Project Description

Neuronal regulation of immune cell function is emerging as a critical regulator of chronic inflammationand neurodegeneration. In this context, the β2-adrenergic receptor (Adrb2) on myeloid cells waslinked to the pathogenesis of chronic inflammatory diseases. We propose to systematically investigateimmune regulation by Adrb2 using conditional deletion of Adrb2 in neutrophils, macrophages, anddendritic cells. These conditional knockout mice will be combined with disease models, nextgenerationsequencing and the modulation of neuronal activation to dissect the molecular pathwaysthat regulate chronic inflammation.
DFG Programme CRC/Transregios
Subproject of TRR 167:  Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
Applicant Institution Albert-Ludwigs-Universität Freiburg
Project Head Professor Dr. Christoph Siegfried Niki Klose