Project Details
Projekt
USP18 as a key regulator for microglia activation (B16*)
Subject Area
Experimental Models for the Understanding of Nervous System Diseases
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024
USP18, a major negative regulator of the type I IFN response, is controlled by the interacting proteinsSTAT2 and ISG15. USP18 loss-of-function mutations cause hyperactivation of microglia andinterferonopathy in humans. This project aims to define how USP18 controls specific myeloid cellsubsets in the CNS both in steady state and upon infection. Focusing on the crosstalk of ISG15 withUSP18 in a novel humanized mouse model and new interacting partners, we will investigate the IFNdependentactivation of microglia, held in check by USP18 with the final aim of therapeuticintervention.
DFG Programme
CRC/Transregios
Subproject of
TRR 167:
Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
Applicant Institution
Albert-Ludwigs-Universität Freiburg
