Mechanisms and consequences of microglia elimination during postnatal development
(A09*)
Subject Area
Immunology
Experimental Models for the Understanding of Nervous System Diseases
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024
The microglia network is involved in neuronal circuit maturation or myelinogenesis during postnatal development, accompanied by exponential clonal expansion with proliferative bouts of microglia, temporarily leading to overshooting microglial cell numbers. Excess microglia need to be eliminated without disturbing brain development by cell death itself or ensuing immune activation. Yet, the cell death-inducing factors, precise cell death modalities and mechanisms of recognition and removal of dying cells are underexplored and will be investigated here.
DFG Programme
CRC/Transregios
