The role of cyclic nucleotides in the regulation of adipose tissue resident myeloid cells (P17)

Subject Area Immunology
Endocrinology, Diabetology, Metabolism
Nutritional Sciences
Pharmacology
Term from 2021 to 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352
 

Project Description

This project aims to investigate the role of cyclic GMP (cGMP) signalling in myeloid cells during metaflammation. Although myeloid cells play an outstanding role in adipose tissue (AT) inflammation, not much is known about the signalling pathways involved. Our previous work shows that cGMP signaling is negatively affected in adipose tissue during obesity. In this project, we will identify the cGMP signalling components in AT-resident macrophages and the effect of cGMP on macrophage function during metaflammation. Furthermore, we will analyse cGMP signalling in vivo and in human macrophages during obesity and metaflammation.
DFG Programme Collaborative Research Centres
Subproject of SFB 1454:  Metaflammation and Cellular Programming
Applicant Institution Rheinische Friedrich-Wilhelms-Universität Bonn
Project Head Professor Dr. Alexander Pfeifer